SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 VAL A  75
ASP A  76
ASP A  88
ARG A 137
GLY A 131
 None
NAD  A 279 (-3.2A)
None
None
None
 1.28A 1ia0B-3t7cA:
5.9		 1ia0B-3t7cA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 VAL A  75
ASP A  76
ASP A  88
ARG A 137
GLY A 131
 None
NAD  A 279 (-3.2A)
None
None
None
 1.28A 1tubB-3t7cA:
6.9		 1tubB-3t7cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		7 / 11 GLY A  14
ALA A  16
ASP A  38
ASP A  76
VAL A  77
ALA A 104
VAL A 127
 NAD  A 279 (-3.5A)
NAD  A 279 ( 4.0A)
NAD  A 279 (-2.8A)
NAD  A 279 (-3.2A)
NAD  A 279 (-3.5A)
NAD  A 279 (-3.6A)
NAD  A 279 (-4.0A)
 0.25A 1uayA-3t7cA:
29.5		 1uayA-3t7cA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		7 / 10 GLY A  14
ALA A  16
ASP A  38
ASP A  76
VAL A  77
ALA A 104
VAL A 127
 NAD  A 279 (-3.5A)
NAD  A 279 ( 4.0A)
NAD  A 279 (-2.8A)
NAD  A 279 (-3.2A)
NAD  A 279 (-3.5A)
NAD  A 279 (-3.6A)
NAD  A 279 (-4.0A)
 0.26A 1uayB-3t7cA:
29.8		 1uayB-3t7cA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 GLY A  14
ASP A  38
ASP A  76
ASN A 103
ALA A 104
 NAD  A 279 (-3.5A)
NAD  A 279 (-2.8A)
NAD  A 279 (-3.2A)
NAD  A 279 (-3.3A)
NAD  A 279 (-3.6A)
 0.91A 2bm9E-3t7cA:
4.8		 2bm9E-3t7cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		3 / 3 LYS A 119
ASP A  76
ASP A  38
 None
NAD  A 279 (-3.2A)
NAD  A 279 (-2.8A)
 1.06A 2br4A-3t7cA:
5.3		 2br4A-3t7cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 LEU A 101
ASP A  98
GLY A 150
VAL A   5
ALA A  32
 None
 1.20A 2kceA-3t7cA:
undetectable		 2kceA-3t7cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 8 LEU A 177
THR A 135
ALA A 105
ALA A 104
 None
None
NAD  A 279 (-3.3A)
NAD  A 279 (-3.6A)
 0.90A 3ax9B-3t7cA:
undetectable		 3ax9B-3t7cA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 6 ILE A  34
VAL A  63
ARG A  68
LEU A  66
 None
 0.82A 3kp6A-3t7cA:
undetectable
3kp6B-3t7cA:
undetectable		 3kp6A-3t7cA:
20.33
3kp6B-3t7cA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 5 ASP A  76
GLY A 131
VAL A 127
THR A  13
 NAD  A 279 (-3.2A)
None
NAD  A 279 (-4.0A)
None
 1.11A 3vqrB-3t7cA:
5.5		 3vqrB-3t7cA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 9 GLU A 187
ILE A 193
VAL A 195
ALA A 136
ILE A 152
 None
 1.05A 4lbgB-3t7cA:
6.4		 4lbgB-3t7cA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 11 ILE A  37
ALA A  15
LEU A 101
LEU A  97
ILE A  35
 None
 1.14A 4p66A-3t7cA:
undetectable		 4p66A-3t7cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 VAL A  77
LEU A  56
ALA A  16
THR A 135
ALA A  72
 NAD  A 279 (-3.5A)
None
NAD  A 279 ( 4.0A)
None
None
 1.18A 4x1kA-3t7cA:
6.1
4x1kB-3t7cA:
6.5		 4x1kA-3t7cA:
21.25
4x1kB-3t7cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 6 LEU A  94
ILE A  71
ALA A  72
ALA A  24
 None
 0.74A 4zf8A-3t7cA:
undetectable		 4zf8A-3t7cA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 ILE A 143
ILE A 152
ALA A 102
THR A  13
ILE A  37
 None
 0.93A 5vceA-3t7cA:
undetectable		 5vceA-3t7cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3t7c CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 GLY A  67
LEU A 101
ARG A  68
ILE A  34
ASP A  33
 None
 1.06A 6bxmA-3t7cA:
undetectable		 6bxmA-3t7cA:
22.60