SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  46
GLU A 274
ALA A  12
THR A 208
VAL A  58
 None
 1.22A 1ictA-3t7fA:
undetectable
1ictC-3t7fA:
undetectable		 1ictA-3t7fA:
19.93
1ictC-3t7fA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  65
SER A 127
TYR A 138
 None
 0.63A 1x70A-3t7fA:
undetectable		 1x70A-3t7fA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 228
TYR A 192
ILE A 117
 None
 0.85A 3eteA-3t7fA:
undetectable
3eteB-3t7fA:
undetectable		 3eteA-3t7fA:
19.05
3eteB-3t7fA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 128
LYS A  29
SER A  26
 None
 1.20A 3tyeB-3t7fA:
undetectable		 3tyeB-3t7fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 237
LEU A 161
GLU A 158
SER A 160
 None
 1.00A 4tvtA-3t7fA:
undetectable		 4tvtA-3t7fA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 281
PHE A  13
GLY A 141
LEU A  17
LEU A  46
 None
 1.25A 5y2tA-3t7fA:
undetectable		 5y2tA-3t7fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 206
ILE A 241
ILE A 189
LEU A 153
LEU A 226
 None
 1.02A 5ycnA-3t7fA:
undetectable		 5ycnA-3t7fA:
20.68