SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 857
PHE A 849
ILE A 906
PHE A 878
 None
 0.96A 2opxA-3t7iA:
undetectable		 2opxA-3t7iA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 974
LEU A 975
GLY A 972
PRO A 965
LYS A1018
 None
 1.15A 3bjwF-3t7iA:
undetectable		 3bjwF-3t7iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 835
LEU A 927
LYS A 902
ILE A 906
ILE A 913
 None
 1.22A 3kz7A-3t7iA:
undetectable		 3kz7A-3t7iA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 864
ILE A 862
ASP A 853
ILE A 854
LEU A 910
 None
 1.29A 3o1cA-3t7iA:
undetectable		 3o1cA-3t7iA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 864
ILE A 862
ASP A 853
ILE A 854
LEU A 910
 None
 1.29A 3o1xA-3t7iA:
undetectable		 3o1xA-3t7iA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 835
LEU A 860
LEU A 927
ILE A 906
ILE A 913
 None
 1.01A 4odrA-3t7iA:
undetectable
4odrB-3t7iA:
undetectable		 4odrA-3t7iA:
14.45
4odrB-3t7iA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 835
LEU A 927
LYS A 902
ILE A 906
ILE A 913
 None
 1.19A 5gpgA-3t7iA:
undetectable		 5gpgA-3t7iA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 878
ILE A 906
GLY A 848
PHE A 845
VAL A 852
 None
 1.13A 5x66F-3t7iA:
undetectable		 5x66F-3t7iA:
21.79