SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 10 THR A  73
GLY A 100
LEU A 108
PHE A 110
GLY A 103
None
1.36A 1h4oA-3t7sA:
undetectable
1h4oB-3t7sA:
undetectable
1h4oA-3t7sA:
20.80
1h4oB-3t7sA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 10 LEU A 108
ALA A  51
ILE A 118
CYH A  55
GLY A  54
None
None
None
None
SAM  A 300 (-3.7A)
1.06A 2b17A-3t7sA:
undetectable
2b17A-3t7sA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
4 / 7 GLY A  27
SER A 151
SER A 149
GLU A 150
SAM  A 300 (-4.1A)
None
None
None
0.95A 2c8aD-3t7sA:
undetectable
2c8aD-3t7sA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
4 / 6 ASP A 116
TYR A 145
PHE A 110
LEU A  53
None
1.19A 2w98A-3t7sA:
7.0
2w98B-3t7sA:
6.7
2w98A-3t7sA:
21.93
2w98B-3t7sA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
4 / 4 ARG A 131
GLY A 132
GLU A 135
SER A 151
None
1.36A 2xctS-3t7sA:
undetectable
2xctU-3t7sA:
undetectable
2xctS-3t7sA:
17.73
2xctU-3t7sA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
4 / 6 ARG A  25
ILE A 202
GLU A 236
TYR A 247
SAM  A 300 (-4.0A)
None
None
None
1.14A 2ya7C-3t7sA:
undetectable
2ya7C-3t7sA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 9 LEU A 146
ILE A  72
GLY A  74
ILE A  75
VAL A 148
None
1.10A 3d1yB-3t7sA:
undetectable
3d1yB-3t7sA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
9 / 12 ARG A  25
GLY A  54
GLY A  56
GLN A  60
PHE A  77
SER A 104
GLU A 121
ALA A 123
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-2.8A)
None
SAM  A 300 (-3.6A)
SAM  A 300 (-3.1A)
0.40A 3kkzA-3t7sA:
39.9
3kkzA-3t7sA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
10 / 12 ARG A  25
GLY A  27
GLY A  54
GLY A  56
GLN A  60
PHE A  77
SER A 104
GLU A 121
ALA A 123
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-4.1A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-4.7A)
SAM  A 300 (-2.8A)
None
SAM  A 300 (-3.6A)
SAM  A 300 (-3.1A)
0.28A 3kkzB-3t7sA:
40.1
3kkzB-3t7sA:
69.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
3 / 3 GLU A 150
PHE A 252
GLN A 182
None
0.98A 3r55A-3t7sA:
undetectable
3r55A-3t7sA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
10 / 12 ARG A  25
GLY A  54
GLY A  56
GLN A  60
SER A 104
MET A 105
GLU A 121
ALA A 123
TYR A 125
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
None
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.1A)
0.49A 3sxjA-3t7sA:
38.8
3sxjA-3t7sA:
59.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
10 / 12 ARG A  25
GLY A  54
GLY A  56
GLN A  60
SER A 104
MET A 105
GLU A 121
ALA A 123
TYR A 125
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
None
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.1A)
0.48A 3sxjB-3t7sA:
38.8
3sxjB-3t7sA:
59.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
12 / 12 ARG A  25
GLN A  26
GLY A  54
GLY A  56
GLN A  60
ASP A  76
PHE A  77
SER A 104
MET A 105
GLU A 121
ALA A 123
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.7A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
None
SAM  A 300 (-3.6A)
SAM  A 300 (-3.1A)
0.00A 3t7sA-3t7sA:
45.7
3t7sA-3t7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
11 / 12 ARG A  25
GLY A  54
GLY A  56
GLN A  60
ASP A  76
PHE A  77
SER A 104
MET A 105
GLU A 121
ALA A 123
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.7A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
None
SAM  A 300 (-3.6A)
SAM  A 300 (-3.1A)
0.27A 3t7sB-3t7sA:
40.8
3t7sB-3t7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 12 GLN A  26
GLY A  54
GLY A  56
ASP A  76
ALA A 123
SAM  A 300 (-3.5A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-3.6A)
1.22A 3t7sB-3t7sA:
40.8
3t7sB-3t7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
11 / 12 ARG A  25
GLN A  26
GLY A  54
GLY A  56
GLN A  60
SER A 104
MET A 105
GLU A 121
ALA A 123
TYR A 125
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
None
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.1A)
0.15A 3t7sC-3t7sA:
43.0
3t7sC-3t7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
11 / 12 ARG A  25
GLY A  54
GLY A  56
GLN A  60
ASP A  76
PHE A  77
SER A 104
MET A 105
GLU A 121
ALA A 123
ASN A 126
SAM  A 300 (-4.0A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.7A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
None
SAM  A 300 (-3.6A)
SAM  A 300 (-3.1A)
0.28A 3t7sD-3t7sA:
38.4
3t7sD-3t7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 12 GLN A  26
GLY A  54
GLY A  56
ASP A  76
ALA A 123
SAM  A 300 (-3.5A)
SAM  A 300 (-3.7A)
SAM  A 300 (-3.4A)
SAM  A 300 (-2.8A)
SAM  A 300 (-3.6A)
1.24A 3t7sD-3t7sA:
38.4
3t7sD-3t7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 11 GLY A 122
TYR A 125
SER A 149
TYR A 205
GLY A  29
SAM  A 300 (-4.5A)
None
None
None
None
1.33A 4ey7A-3t7sA:
2.2
4ey7A-3t7sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 11 GLY A 122
TYR A 125
SER A 149
TYR A 205
GLY A  29
SAM  A 300 (-4.5A)
None
None
None
None
1.34A 4ey7B-3t7sA:
2.0
4ey7B-3t7sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 12 ASN A  43
ILE A  41
GLY A 144
ILE A 183
VAL A 191
None
0.88A 4nkxA-3t7sA:
undetectable
4nkxA-3t7sA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
5 / 12 ASP A  52
GLY A  54
THR A  61
ASP A  76
MET A 105
None
SAM  A 300 (-3.7A)
None
SAM  A 300 (-2.8A)
SAM  A 300 (-4.1A)
1.40A 4pghB-3t7sA:
13.1
4pghB-3t7sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
4 / 7 GLU A 236
TYR A 249
LEU A 196
TYR A 205
None
1.20A 4twdF-3t7sA:
undetectable
4twdJ-3t7sA:
undetectable
4twdF-3t7sA:
22.29
4twdJ-3t7sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus)
3 / 3 HIS A 234
ARG A 217
ILE A 230
None
0.87A 6fgdA-3t7sA:
undetectable
6fgdA-3t7sA:
20.42