SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		5 / 12 ALA A 101
VAL A  34
GLY A  63
ALA A 171
ILE A 165
 None
 1.21A 1kxhA-3t8jA:
undetectable		 1kxhA-3t8jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		4 / 6 TYR A  72
ILE A  38
GLU A  76
PHE A 163
 None
 1.40A 1oniA-3t8jA:
undetectable
1oniC-3t8jA:
undetectable		 1oniA-3t8jA:
18.45
1oniC-3t8jA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		5 / 12 PRO A 186
ILE A 291
VAL A 259
ILE A 165
VAL A 151
 None
 1.20A 1z9hD-3t8jA:
undetectable		 1z9hD-3t8jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		4 / 7 VAL A  31
ALA A  47
PHE A 118
THR A 242
 None
 0.99A 2q6oA-3t8jA:
2.3		 2q6oA-3t8jA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		5 / 11 LEU A 116
LEU A  21
VAL A  28
ILE A 121
VAL A  31
 None
None
None
NA  A 401 (-4.3A)
None
 1.18A 2uxoB-3t8jA:
undetectable		 2uxoB-3t8jA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		4 / 7 ASP A   9
ASP A  14
GLN A  42
GLU A  43
 NA  A 401 (-3.2A)
NA  A 401 (-2.6A)
None
None
 1.22A 3l2vA-3t8jA:
undetectable		 3l2vA-3t8jA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		3 / 3 TYR A 221
ASP A 238
ASP A   7
 None
NA  A 401 ( 3.9A)
None
 0.87A 3ou6B-3t8jA:
2.2		 3ou6B-3t8jA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		4 / 4 ASN A 309
SER A  17
LEU A  20
THR A 208
 None
 1.49A 4an2A-3t8jA:
undetectable		 4an2A-3t8jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		4 / 5 THR A 241
THR A 242
THR A  10
ASN A 164
 None
None
None
NA  A 401 ( 4.7A)
 1.33A 4pgfB-3t8jA:
7.8		 4pgfB-3t8jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		5 / 12 GLY A  63
ILE A 185
GLY A 149
LEU A 124
PHE A 118
 None
 1.21A 4zdyA-3t8jA:
undetectable		 4zdyA-3t8jA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		5 / 12 ASP A  13
SER A  17
VAL A  78
ASN A 164
VAL A 167
 None
None
None
NA  A 401 ( 4.7A)
None
 1.20A 5tudD-3t8jA:
undetectable		 5tudD-3t8jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3t8j PURINE NUCLEOSIDASE,
(IUNH-1)
(Sulfolobus
solfataricus) 		4 / 7 ALA A  96
LYS A  45
GLU A  90
LEU A  51
 None
 0.94A 6ci6A-3t8jA:
undetectable		 6ci6A-3t8jA:
14.72