SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B82_A_ADNA1001_1 (CLASS B ACID PHOSPHATASE)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	5 / 10	PHE A 57 LYS A 53 GLU A 17 TYR A 16 LEU A 20	None	1.45A	2b82A-3t8kA: undetectable	2b82A-3t8kA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B82_B_ADNB1002_1 (CLASS B ACID PHOSPHATASE)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	5 / 9	PHE A 57 LYS A 53 GLU A 17 TYR A 16 LEU A 20	None	1.48A	2b82B-3t8kA: 0.0	2b82B-3t8kA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_C_STIC600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	4 / 6	LEU A 132 LYS A 95 MET A 56 ILE A 96	None	1.03A	2hyyC-3t8kA: undetectable	2hyyC-3t8kA: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_B_MTXB164_2 (DIHYDROFOLATE REDUCTASE)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	4 / 4	PHE A 116 LYS A 117 ILE A 136 THR A 74	None	1.35A	3ia4B-3t8kA: undetectable	3ia4B-3t8kA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZU_A_X89A411_1 (FLAVOHEMOPROTEIN)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	5 / 12	ILE A 65 LEU A 39 VAL A 42 LEU A 93 TYR A 52	None	1.35A	3ozuA-3t8kA: undetectable	3ozuA-3t8kA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UY8_7_TRP71002_0 (TRYPTOPHANASE)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	4 / 4	ILE A 119 ASN A 118 ILE A 113 VAL A 114	None	1.25A	4uy87-3t8kA: undetectable	4uy87-3t8kA: 6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP6_A_B40A601_1 (TRANSPORTER)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	4 / 5	ASP A 29 VAL A 7 PHE A 23 GLY A 26	None	1.20A	4xp6A-3t8kA: undetectable	4xp6A-3t8kA: 14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I6X_A_8PRA705_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	3t8k	UNCHARACTERIZED PROTEIN (Leptotrichia buccalis)	5 / 10	TYR A 122 ILE A 136 TYR A 133 PHE A 80 VAL A 115	None	1.06A	5i6xA-3t8kA: undetectable	5i6xA-3t8kA: 16.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2B82_A_ADNA1001_1","CLASS B ACID PHOSPHATASE","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",5,"PHE A  57;LYS A  53;GLU A  17;TYR A  16;LEU A  20","None","1.45A","2b82A-3t8kA:undetectable","2b82A-3t8kA:22.27"],["2B82_B_ADNB1002_1","CLASS B ACID PHOSPHATASE","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",5,"PHE A  57;LYS A  53;GLU A  17;TYR A  16;LEU A  20","None","1.48A","2b82B-3t8kA:0.0","2b82B-3t8kA:22.27"],["2HYY_C_STIC600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",4,"LEU A 132;LYS A  95;MET A  56;ILE A  96","None","1.03A","2hyyC-3t8kA:undetectable","2hyyC-3t8kA:20.21"],["3IA4_B_MTXB164_2","DIHYDROFOLATE REDUCTASE","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",4,"PHE A 116;LYS A 117;ILE A 136;THR A  74","None","1.35A","3ia4B-3t8kA:undetectable","3ia4B-3t8kA:20.87"],["3OZU_A_X89A411_1","FLAVOHEMOPROTEIN","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",5,"ILE A  65;LEU A  39;VAL A  42;LEU A  93;TYR A  52","None","1.35A","3ozuA-3t8kA:undetectable","3ozuA-3t8kA:19.35"],["4UY8_7_TRP71002_0","TRYPTOPHANASE","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",4,"ILE A 119;ASN A 118;ILE A 113;VAL A 114","None","1.25A","4uy87-3t8kA:undetectable","4uy87-3t8kA:6.59"],["4XP6_A_B40A601_1","TRANSPORTER","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",4,"ASP A  29;VAL A   7;PHE A  23;GLY A  26","None","1.20A","4xp6A-3t8kA:undetectable","4xp6A-3t8kA:14.31"],["5I6X_A_8PRA705_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","3t8k","UNCHARACTERIZED PROTEIN","Leptotrichia buccalis",5,"TYR A 122;ILE A 136;TYR A 133;PHE A  80;VAL A 115","None","1.06A","5i6xA-3t8kA:undetectable","5i6xA-3t8kA:16.30"]]