SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		3 / 3 VAL A 351
VAL A 349
TRP A  28
 None
 0.61A 1av2C-3t8qA:
undetectable
1av2D-3t8qA:
undetectable		 1av2C-3t8qA:
8.14
1av2D-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 5 GLU A   7
THR A   8
HIS A  44
LEU A  52
 None
 1.30A 1d4fC-3t8qA:
undetectable		 1d4fC-3t8qA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4001_1
(SERUM ALBUMIN)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 4 ARG A 113
LYS A 338
ASP A 142
GLY A 140
 None
 1.47A 1e7bB-3t8qA:
0.2		 1e7bB-3t8qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		5 / 12 TYR A 332
VAL A  14
ALA A 329
SER A 330
LEU A 344
 None
 1.30A 1kiaD-3t8qA:
2.1		 1kiaD-3t8qA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 4 LEU A  85
VAL A  17
CYH A  15
ALA A  10
 None
 1.15A 1mz9E-3t8qA:
undetectable		 1mz9E-3t8qA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 4 GLY A  83
VAL A  31
TRP A 347
GLY A  29
 None
 1.13A 1ng8A-3t8qA:
undetectable		 1ng8A-3t8qA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 4 GLY A  83
VAL A  31
TRP A 347
GLY A  29
 None
 1.13A 1ng8B-3t8qA:
undetectable		 1ng8B-3t8qA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 4 ALA A 143
VAL A 178
ALA A 179
HIS A 207
 None
 1.15A 1q23A-3t8qA:
undetectable		 1q23A-3t8qA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 4 ALA A 143
VAL A 178
ALA A 179
HIS A 207
 None
 1.22A 1q23K-3t8qA:
undetectable		 1q23K-3t8qA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		3 / 3 VAL A 351
VAL A 349
TRP A  28
 None
 0.65A 1w5uC-3t8qA:
undetectable
1w5uD-3t8qA:
undetectable		 1w5uC-3t8qA:
8.14
1w5uD-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		3 / 3 VAL A 349
TRP A  28
VAL A 351
 None
 0.68A 2izqA-3t8qA:
undetectable
2izqB-3t8qA:
undetectable		 2izqA-3t8qA:
8.14
2izqB-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		5 / 12 ALA A  81
GLY A  84
GLY A 264
THR A   8
VAL A  17
 None
 1.10A 2okcA-3t8qA:
undetectable		 2okcA-3t8qA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 8 ALA A 184
GLY A 197
ILE A 229
THR A 220
 None
 0.82A 3el9A-3t8qA:
undetectable		 3el9A-3t8qA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		3 / 3 VAL A 351
VAL A 349
TRP A  28
 None
 0.64A 3l8lA-3t8qA:
undetectable
3l8lB-3t8qA:
undetectable		 3l8lA-3t8qA:
8.14
3l8lB-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		3 / 3 VAL A 351
VAL A 349
TRP A  28
 None
 0.72A 3l8lC-3t8qA:
undetectable
3l8lD-3t8qA:
undetectable		 3l8lC-3t8qA:
8.14
3l8lD-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		5 / 12 GLN A 256
GLN A 236
ASP A 183
SER A 118
MET A 119
 None
None
MG  A 369 (-2.7A)
None
None
 1.31A 3t7sA-3t8qA:
undetectable		 3t7sA-3t8qA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		5 / 12 LEU A  62
ALA A  48
LEU A  89
GLY A  53
VAL A  19
 None
 0.97A 4nkvB-3t8qA:
undetectable		 4nkvB-3t8qA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		5 / 11 ILE A 170
MET A 199
PHE A 146
LYS A 145
ILE A 166
 None
None
None
MG  A 369 ( 3.8A)
None
 1.37A 4p68A-3t8qA:
undetectable		 4p68A-3t8qA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 5 HIS A 207
VAL A 231
GLU A 209
LYS A 145
 None
None
MG  A 369 (-3.2A)
MG  A 369 ( 3.8A)
 1.39A 4p6vB-3t8qA:
undetectable
4p6vE-3t8qA:
undetectable		 4p6vB-3t8qA:
21.10
4p6vE-3t8qA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 7 CYH A 282
ILE A 254
GLN A 256
PRO A 257
 None
 1.02A 4w5oA-3t8qA:
2.3		 4w5oA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 8 LEU A  89
ALA A  56
MET A   1
ILE A   3
 None
 0.61A 4wboB-3t8qA:
undetectable		 4wboB-3t8qA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 7 CYH A 282
GLN A 256
PRO A 257
ASP A 258
 None
 0.93A 4z4eA-3t8qA:
undetectable		 4z4eA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 7 CYH A 282
ILE A 254
GLN A 256
PRO A 257
 None
 1.07A 4z4eA-3t8qA:
undetectable		 4z4eA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 7 CYH A 282
GLN A 256
PRO A 257
ASP A 258
 None
 0.91A 4z4gA-3t8qA:
2.6		 4z4gA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 7 CYH A 282
ILE A 254
GLN A 256
PRO A 257
 None
 1.03A 4z4gA-3t8qA:
2.6		 4z4gA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		5 / 12 GLU A 317
GLY A 316
MET A 119
GLU A 311
LEU A 289
 None
 1.23A 5fhzD-3t8qA:
2.2		 5fhzD-3t8qA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		5 / 12 GLU A 317
GLY A 316
MET A 119
GLU A 311
THR A 293
 None
 1.39A 5fhzD-3t8qA:
2.2		 5fhzD-3t8qA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 7 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.89A 5u4sA-3t8qA:
undetectable		 5u4sA-3t8qA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Hoeflea
phototrophica) 		4 / 8 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sB-3t8qA:
2.3		 5u4sB-3t8qA:
20.27