SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 ALA A 429
VAL A 399
TRP A 398
 None
 0.88A 1grmA-3t8sA:
undetectable		 1grmA-3t8sA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 ALA A 429
VAL A 399
TRP A 398
 None
 0.87A 1grmB-3t8sA:
undetectable		 1grmB-3t8sA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		5 / 8 GLN A 513
LEU A 443
ASP A 444
LEU A  32
GLY A  31
 None
 1.43A 2qqcH-3t8sA:
undetectable
2qqcK-3t8sA:
undetectable		 2qqcH-3t8sA:
11.76
2qqcK-3t8sA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 7 ASP A 180
GLN A 116
PRO A 165
GLN A 164
 None
 1.21A 3l2vA-3t8sA:
undetectable		 3l2vA-3t8sA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 5 VAL A 177
VAL A 176
ARG A 170
LYS A 219
 None
 1.27A 3rv5A-3t8sA:
undetectable
3rv5B-3t8sA:
undetectable		 3rv5A-3t8sA:
8.03
3rv5B-3t8sA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 8 SER A 277
SER A 278
ARG A 241
GLN A 513
 None
 0.77A 4af0A-3t8sA:
undetectable		 4af0A-3t8sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 8 TYR A 117
ILE A 220
VAL A 182
ILE A 121
 None
 0.90A 5mzrE-3t8sA:
3.1		 5mzrE-3t8sA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		4 / 6 ASN A 362
ASP A 363
SER A 366
ARG A 304
 None
 1.13A 6dwdA-3t8sA:
undetectable
6dwdC-3t8sA:
undetectable		 6dwdA-3t8sA:
22.92
6dwdC-3t8sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Rattus
norvegicus) 		3 / 3 TRP A 218
ILE A  27
GLU A 208
 None
 0.62A 6hcxA-3t8sA:
undetectable		 6hcxA-3t8sA:
8.33