SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PK2_A_ACAA91_1 (TISSUE-TYPE PLASMINOGEN ACTIVATOR)	3t8y	CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE (Thermotoga maritima)	4 / 8	VAL A 20 ASP A 12 ASP A 13 LEU A 116	None PB A 145 ( 4.4A) PB A 145 (-2.7A) None	1.25A	1pk2A-3t8yA: undetectable	1pk2A-3t8yA: 16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R2V_D_ACTD37_0 (GCN4 LEUCINE ZIPPER)	3t8y	CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE (Thermotoga maritima)	3 / 3	LYS A 46 ARG A 18 VAL A 11	None	1.01A	2r2vC-3t8yA: undetectable 2r2vD-3t8yA: undetectable	2r2vC-3t8yA: 12.80 2r2vD-3t8yA: 12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FR0_A_SAMA401_0 (ARSENIC METHYLTRANSFERASE)	3t8y	CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE (Thermotoga maritima)	6 / 12	GLY A 66 GLY A 40 ASP A 13 LEU A 72 ILE A 67 GLU A 97	None None PB A 145 (-2.7A) None None None	1.37A	4fr0A-3t8yA: 2.5	4fr0A-3t8yA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XJE_A_TOYA202_1 (AADB)	3t8y	CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE (Thermotoga maritima)	4 / 8	ASP A 13 ASP A 58 ASP A 12 ILE A 107	PB A 145 (-2.7A) PB A 145 (-2.3A) PB A 145 ( 4.4A) None	1.04A	4xjeA-3t8yA: undetectable	4xjeA-3t8yA: 22.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PK2_A_ACAA91_1","TISSUE-TYPE PLASMINOGEN ACTIVATOR","3t8y","CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE","Thermotoga maritima",4,"VAL A  20;ASP A  12;ASP A  13;LEU A 116","None; PB A 145 ( 4.4A); PB A 145 (-2.7A);None","1.25A","1pk2A-3t8yA:undetectable","1pk2A-3t8yA:16.97"],["2R2V_D_ACTD37_0","GCN4 LEUCINE ZIPPER","3t8y","CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE","Thermotoga maritima",3,"LYS A  46;ARG A  18;VAL A  11","None","1.01A","2r2vC-3t8yA:undetectable;2r2vD-3t8yA:undetectable","2r2vC-3t8yA:12.80;2r2vD-3t8yA:12.80"],["4FR0_A_SAMA401_0","ARSENIC METHYLTRANSFERASE","3t8y","CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE","Thermotoga maritima",6,"GLY A  66;GLY A  40;ASP A  13;LEU A  72;ILE A  67;GLU A  97","None;None; PB A 145 (-2.7A);None;None;None","1.37A","4fr0A-3t8yA:2.5","4fr0A-3t8yA:19.56"],["4XJE_A_TOYA202_1","AADB","3t8y","CHEMOTAXIS RESPONSE REGULATOR PROTEIN-GLUTAMATE METHYLESTERASE","Thermotoga maritima",4,"ASP A  13;ASP A  58;ASP A  12;ILE A 107"," PB A 145 (-2.7A); PB A 145 (-2.3A); PB A 145 ( 4.4A);None","1.04A","4xjeA-3t8yA:undetectable","4xjeA-3t8yA:22.92"]]