SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 10 GLY A  94
PHE A 170
GLY A 189
MET A 190
THR A 213
 MTA  A 901 (-3.6A)
MTA  A 901 (-4.9A)
MTA  A 901 (-3.5A)
MTA  A 901 (-3.9A)
MTA  A 901 ( 4.7A)
 0.40A 1pwyE-3t94A:
25.6		 1pwyE-3t94A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		4 / 8 GLY A 189
ALA A 210
THR A 213
ILE A 187
 MTA  A 901 (-3.5A)
None
MTA  A 901 ( 4.7A)
None
 0.81A 1utdF-3t94A:
undetectable
1utdG-3t94A:
undetectable		 1utdF-3t94A:
16.48
1utdG-3t94A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 10 GLY A  94
PHE A 170
GLY A 189
MET A 190
THR A 213
 MTA  A 901 (-3.6A)
MTA  A 901 (-4.9A)
MTA  A 901 (-3.5A)
MTA  A 901 (-3.9A)
MTA  A 901 ( 4.7A)
 0.39A 1v3qE-3t94A:
26.1		 1v3qE-3t94A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		6 / 12 SER A  16
ALA A  92
GLY A  94
GLY A 189
MET A 190
VAL A 228
 SO4  A 902 ( 2.6A)
SO4  A 902 ( 3.8A)
MTA  A 901 (-3.6A)
MTA  A 901 (-3.5A)
MTA  A 901 (-3.9A)
MTA  A 901 ( 4.4A)
 0.41A 3f8wA-3t94A:
27.2		 3f8wA-3t94A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 12 SER A  16
GLY A  94
GLY A 189
MET A 190
VAL A 228
 SO4  A 902 ( 2.6A)
MTA  A 901 (-3.6A)
MTA  A 901 (-3.5A)
MTA  A 901 (-3.9A)
MTA  A 901 ( 4.4A)
 0.37A 3f8wB-3t94A:
27.2		 3f8wB-3t94A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 12 HIS A  59
ALA A  92
GLY A  94
GLY A 189
VAL A 228
 SO4  A 902 ( 3.9A)
SO4  A 902 ( 3.8A)
MTA  A 901 (-3.6A)
MTA  A 901 (-3.5A)
MTA  A 901 ( 4.4A)
 1.06A 3f8wC-3t94A:
27.3		 3f8wC-3t94A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		6 / 12 SER A  16
ALA A  92
GLY A  94
GLY A 189
MET A 190
VAL A 228
 SO4  A 902 ( 2.6A)
SO4  A 902 ( 3.8A)
MTA  A 901 (-3.6A)
MTA  A 901 (-3.5A)
MTA  A 901 (-3.9A)
MTA  A 901 ( 4.4A)
 0.37A 3f8wC-3t94A:
27.3		 3f8wC-3t94A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 11 ALA A  92
ILE A  12
LEU A 243
ILE A 209
THR A 213
 SO4  A 902 ( 3.8A)
None
None
None
MTA  A 901 ( 4.7A)
 0.99A 3tqbA-3t94A:
undetectable		 3tqbA-3t94A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 11 THR A  44
GLY A  46
VAL A  53
SER A  27
ILE A  48
 None
 1.23A 3uawA-3t94A:
4.1		 3uawA-3t94A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		4 / 6 GLY A  37
ALA A  74
TYR A  36
GLU A 119
 None
 0.92A 4ae1A-3t94A:
undetectable		 4ae1A-3t94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 12 PRO A 136
GLY A 160
ILE A 187
PHE A 111
LEU A 192
 None
 1.47A 4kovA-3t94A:
undetectable		 4kovA-3t94A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		5 / 9 SER A 171
TRP A 179
ALA A 185
GLY A  94
ALA A 199
 None
None
None
MTA  A 901 (-3.6A)
None
 1.42A 4l6va-3t94A:
undetectable
4l6vf-3t94A:
undetectable		 4l6va-3t94A:
17.47
4l6vf-3t94A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		3 / 3 ARG A  58
TYR A 206
GLU A 195
 SO4  A 902 (-4.0A)
None
None
 0.49A 4zzbE-3t94A:
undetectable		 4zzbE-3t94A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		4 / 8 VAL A  93
ALA A  92
GLY A  15
SER A  89
 None
SO4  A 902 ( 3.8A)
SO4  A 902 (-3.3A)
None
 0.81A 5e26C-3t94A:
undetectable
5e26D-3t94A:
undetectable		 5e26C-3t94A:
21.05
5e26D-3t94A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		4 / 6 ILE A 209
ALA A 239
LEU A 242
ILE A 154
 None
 0.63A 5mvmB-3t94A:
undetectable
5mvmC-3t94A:
undetectable		 5mvmB-3t94A:
20.50
5mvmC-3t94A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3t94 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(MTAP)
(Sulfolobus
solfataricus) 		4 / 4 LEU A 250
LEU A 246
SER A 140
ALA A 145
 None
 1.05A 5uunA-3t94A:
undetectable		 5uunA-3t94A:
22.01