SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		3 / 3 ALA A  30
VAL A  89
TRP A 114
 None
 0.95A 1c4dA-3t95A:
undetectable
1c4dB-3t95A:
undetectable		 1c4dA-3t95A:
5.63
1c4dB-3t95A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		3 / 3 TRP A 114
ALA A  30
VAL A  89
 None
 0.85A 1c4dA-3t95A:
undetectable
1c4dB-3t95A:
undetectable		 1c4dA-3t95A:
5.63
1c4dB-3t95A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		3 / 3 MET A 138
ASN A 128
GLN A 270
 None
 0.96A 1xoqB-3t95A:
undetectable		 1xoqB-3t95A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		4 / 8 VAL A 267
VAL A 268
GLY A 271
LYS A 272
 None
 0.40A 3bjwA-3t95A:
undetectable		 3bjwA-3t95A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		5 / 12 MET A 138
LEU A 135
GLN A 309
VAL A 308
LEU A 323
 None
 1.20A 3h52A-3t95A:
undetectable		 3h52A-3t95A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		4 / 8 THR A 197
ASP A 195
TYR A 193
PHE A 191
 None
 0.94A 4drjB-3t95A:
undetectable		 4drjB-3t95A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		4 / 7 GLY A 319
VAL A 303
PRO A 305
ASN A 306
 None
 0.35A 4forA-3t95A:
2.5		 4forA-3t95A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		5 / 12 LEU A  55
GLU A  27
LEU A 282
ILE A 295
ILE A 293
 None
 1.21A 4j24B-3t95A:
undetectable		 4j24B-3t95A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		3 / 4 SER A 160
GLY A  96
GLU A 121
 None
 0.48A 4juoA-3t95A:
undetectable
4juoC-3t95A:
3.1		 4juoA-3t95A:
22.22
4juoC-3t95A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		5 / 12 SER A  90
MET A 142
MET A 138
LEU A 323
GLY A  44
 PAV  A 400 ( 4.5A)
None
None
None
None
 1.39A 4zjlA-3t95A:
1.6		 4zjlA-3t95A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		4 / 8 LEU A  55
GLU A  27
LEU A 282
MET A 281
 None
 1.24A 5dxeA-3t95A:
undetectable		 5dxeA-3t95A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		3 / 3 ILE A 295
PRO A 296
ILE A 298
 None
 0.38A 5hw8F-3t95A:
undetectable		 5hw8F-3t95A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		5 / 12 MET A 138
LEU A 135
GLN A 309
VAL A 308
LEU A 323
 None
 1.29A 5uc3B-3t95A:
undetectable		 5uc3B-3t95A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		4 / 6 GLU A 121
ARG A 123
ASP A 117
ASP A 312
 None
 1.31A 5zw4A-3t95A:
2.9		 5zw4A-3t95A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB
(Yersinia
pestis) 		4 / 8 LEU A  55
GLU A  27
LEU A 282
MET A 281
 None
 1.21A 6cbzA-3t95A:
undetectable		 6cbzA-3t95A:
12.35