SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3t9o DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		4 / 8 ASP A  65
ASP A  67
TYR A 120
TYR A 123
 None
 1.18A 1ceaA-3t9oA:
undetectable
1ceaB-3t9oA:
undetectable		 1ceaA-3t9oA:
17.91
1ceaB-3t9oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 3t9o DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		4 / 7 ASP A  65
ASP A  67
TYR A 120
TYR A 123
 None
 1.25A 1ceaB-3t9oA:
undetectable		 1ceaB-3t9oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 3t9o DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		4 / 7 ASP A  65
ASP A  67
TYR A 120
TYR A 123
 None
 1.18A 1cebB-3t9oA:
undetectable		 1cebB-3t9oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3t9o DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		5 / 10 MET A  75
ALA A  78
PHE A 113
PHE A  54
LEU A  15
 None
 1.47A 4la0A-3t9oA:
3.7		 4la0A-3t9oA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 3t9o DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		5 / 9 MET A  75
ALA A  78
PHE A 113
PHE A  54
LEU A  15
 None
 1.40A 4la0B-3t9oA:
3.6		 4la0B-3t9oA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3t9o DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		4 / 8 LEU A  89
GLY A  86
GLU A  88
ALA A  78
 None
 0.90A 4rjdA-3t9oA:
undetectable
4rjdB-3t9oA:
undetectable		 4rjdA-3t9oA:
17.36
4rjdB-3t9oA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3t9o DIGUANYLATE CYCLASE
DGCZ
(Escherichia
coli) 		3 / 3 HIS A  79
HIS A  83
HIS A  22
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
 0.31A 5zrdA-3t9oA:
undetectable		 5zrdA-3t9oA:
13.84