SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3t9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 5 GLU A  29
THR A  30
HIS A  66
LEU A  74
 None
 1.17A 1d4fC-3t9pA:
undetectable		 1d4fC-3t9pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 7 PHE A 349
GLN A  52
VAL A  36
TRP A 344
 None
 1.43A 1jqdA-3t9pA:
2.1		 1jqdA-3t9pA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 GLU A 333
LYS A 167
GLU A 257
GLU A 231
 None
None
FMT  A 391 (-3.6A)
None
 1.15A 1knyA-3t9pA:
undetectable
1knyB-3t9pA:
undetectable		 1knyA-3t9pA:
18.69
1knyB-3t9pA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 10 PHE A  65
ALA A  70
LEU A  74
LEU A  28
LEU A 100
 None
 0.96A 2bxqA-3t9pA:
undetectable		 2bxqA-3t9pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 ILE A 336
SER A 140
ARG A 156
LEU A 157
 None
 0.96A 2cdqA-3t9pA:
undetectable		 2cdqA-3t9pA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 7 ALA A 254
ASP A 275
GLY A 228
ILE A 227
 None
 0.87A 2fxdB-3t9pA:
undetectable		 2fxdB-3t9pA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 ILE A 336
GLU A 150
VAL A 192
LEU A 196
ARG A 153
 None
 1.47A 2jj8C-3t9pA:
undetectable		 2jj8C-3t9pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 ALA A 103
GLY A 106
GLY A 286
THR A  30
VAL A  39
 None
 1.05A 2okcA-3t9pA:
undetectable		 2okcA-3t9pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 10 MET A 114
GLY A  49
ARG A  40
ALA A  26
LEU A 111
 None
 1.21A 2vd0B-3t9pA:
undetectable		 2vd0B-3t9pA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 10 GLU A 387
ARG A  24
LEU A  79
ILE A  25
MET A 114
 None
 1.46A 3adsA-3t9pA:
undetectable		 3adsA-3t9pA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 ALA A 254
ASP A 275
GLY A 228
ILE A 227
 None
 0.85A 3el9A-3t9pA:
undetectable		 3el9A-3t9pA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 VAL A 363
VAL A 371
TYR A 354
VAL A 134
 None
 1.03A 3fhxB-3t9pA:
undetectable		 3fhxB-3t9pA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 7 LEU A 127
PRO A 279
GLY A 285
MET A 282
 None
 0.94A 3hcrB-3t9pA:
undetectable		 3hcrB-3t9pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 ALA A 254
ASP A 275
GLY A 228
ILE A 227
SER A 139
 None
 1.08A 3ogqB-3t9pA:
undetectable		 3ogqB-3t9pA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 GLN A 278
GLN A 258
ASP A 205
SER A 140
MET A 141
 None
 1.31A 3t7sA-3t9pA:
undetectable		 3t7sA-3t9pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 7 TRP A 112
LYS A 121
GLY A 368
PRO A 367
 None
 1.36A 3ucbB-3t9pA:
undetectable		 3ucbB-3t9pA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		3 / 3 ASP A 280
TRP A 344
SER A  54
 None
 1.03A 4lrhB-3t9pA:
undetectable		 4lrhB-3t9pA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		3 / 3 ASP A 280
TRP A 344
SER A  54
 None
 1.01A 4lrhF-3t9pA:
undetectable		 4lrhF-3t9pA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 6 ASP A 205
GLY A 256
VAL A 277
HIS A 229
 None
 1.08A 4oltA-3t9pA:
undetectable		 4oltA-3t9pA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 5 HIS A 229
VAL A 253
GLU A 231
LYS A 167
 None
 1.37A 4p6vB-3t9pA:
undetectable
4p6vE-3t9pA:
undetectable		 4p6vB-3t9pA:
21.49
4p6vE-3t9pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		3 / 3 LYS A 167
TRP A 168
SER A 139
 None
 1.32A 5nwwA-3t9pA:
undetectable		 5nwwA-3t9pA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 ALA A 124
PHE A  65
ALA A  70
ALA A  73
THR A  84
 None
 1.35A 6aycA-3t9pA:
undetectable		 6aycA-3t9pA:
9.95