SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ta7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 TRP A  75
VAL A  72
TRP A  16
 None
 1.33A 1c4dC-3ta7A:
undetectable
1c4dD-3ta7A:
undetectable		 1c4dC-3ta7A:
10.39
1c4dD-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		4 / 6 TRP A  75
GLU A   8
ASP A  76
PHE A   4
 None
 1.42A 2a3bB-3ta7A:
undetectable		 2a3bB-3ta7A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 VAL A  72
TRP A  75
TRP A  16
 None
 1.43A 2xdcA-3ta7A:
undetectable
2xdcB-3ta7A:
undetectable		 2xdcA-3ta7A:
10.39
2xdcB-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 TRP A  16
VAL A  72
TRP A  75
 None
 1.43A 2xdcA-3ta7A:
undetectable
2xdcB-3ta7A:
undetectable		 2xdcA-3ta7A:
10.39
2xdcB-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 VAL A  72
TRP A  75
TRP A  16
 None
 1.10A 2xdcC-3ta7A:
undetectable
2xdcD-3ta7A:
undetectable		 2xdcC-3ta7A:
10.39
2xdcD-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 VAL A  72
TRP A  75
TRP A  16
 None
 1.43A 2y5mA-3ta7A:
undetectable
2y5mB-3ta7A:
undetectable		 2y5mA-3ta7A:
10.39
2y5mB-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 VAL A  72
TRP A  75
TRP A  16
 None
 1.42A 2y6nA-3ta7A:
undetectable
2y6nB-3ta7A:
undetectable		 2y6nA-3ta7A:
10.39
2y6nB-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 TRP A  16
VAL A  72
TRP A  75
 None
 1.41A 2y6nA-3ta7A:
undetectable
2y6nB-3ta7A:
undetectable		 2y6nA-3ta7A:
10.39
2y6nB-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		3 / 3 VAL A  72
TRP A  75
TRP A  16
 None
 1.21A 3zq8A-3ta7A:
undetectable
3zq8B-3ta7A:
undetectable		 3zq8A-3ta7A:
10.39
3zq8B-3ta7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN
(Candidatus
Korarchaeum
cryptofilum) 		5 / 12 LEU A  18
GLY A  78
GLY A  96
ILE A  74
ILE A  56
 None
 0.97A 6ecxA-3ta7A:
undetectable		 6ecxA-3ta7A:
16.56