SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		4 / 8 GLU B1090
ARG B1093
ARG B1094
LEU B1084
 None
None
SO4  B   5 (-2.8A)
SO4  B   5 (-4.7A)
 1.05A 1cmaA-3tacB:
undetectable
1cmaB-3tacB:
undetectable		 1cmaA-3tacB:
16.51
1cmaB-3tacB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 ILE B 943
VAL B 903
TRP B 906
LEU B 907
MET B 913
 None
 1.19A 1p5zB-3tacB:
undetectable		 1p5zB-3tacB:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 LEU B1063
LEU B1054
LEU B1051
ALA B1048
ILE B1024
 None
 1.24A 2bxpA-3tacB:
undetectable		 2bxpA-3tacB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 ILE B 939
TRP B 906
LEU B 907
MET B 913
TYR B 917
 None
 1.12A 2no0A-3tacB:
undetectable		 2no0A-3tacB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 ILE B 943
VAL B 903
TRP B 906
LEU B 907
MET B 913
 None
 1.19A 2no0A-3tacB:
undetectable		 2no0A-3tacB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 ILE B 943
VAL B 903
TRP B 906
LEU B 907
MET B 913
 None
 1.09A 2no0B-3tacB:
undetectable		 2no0B-3tacB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 ILE B 939
TRP B 906
LEU B 907
MET B 913
TYR B 917
 None
 1.13A 2ziaB-3tacB:
undetectable		 2ziaB-3tacB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 ILE B 943
VAL B 903
TRP B 906
LEU B 907
MET B 913
 None
 1.17A 2ziaB-3tacB:
undetectable		 2ziaB-3tacB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 9 ILE B 930
MET B 931
LEU B 934
ILE B 939
MET B 913
 None
 1.20A 3zosB-3tacB:
undetectable		 3zosB-3tacB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		4 / 8 SER B1109
SER B1031
ASN B1110
GLY B1077
 SO4  B   1 (-2.3A)
None
None
None
 0.98A 4af0A-3tacB:
undetectable		 4af0A-3tacB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		3 / 3 PRO B 914
MET B 913
TYR B 917
 SO4  B   4 (-4.1A)
None
None
 1.04A 4qa0B-3tacB:
undetectable		 4qa0B-3tacB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		3 / 3 PRO B 914
MET B 913
TYR B 917
 SO4  B   4 (-4.1A)
None
None
 1.07A 4qa0A-3tacB:
undetectable		 4qa0A-3tacB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		5 / 12 ARG B1112
ILE B1114
ALA B1126
ILE B1129
SER B1132
 None
 1.30A 4uroC-3tacB:
undetectable		 4uroC-3tacB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tac LIPRIN-ALPHA-2
(Homo
sapiens) 		4 / 8 CYH B1080
SER B1137
LEU B1032
ILE B1078
 None
 0.98A 4xtaB-3tacB:
undetectable		 4xtaB-3tacB:
22.82