SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 8 LEU A  78
ALA A  71
VAL A  50
TYR A 173
 None
 0.70A 1epbB-3talA:
undetectable		 1epbB-3talA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 8 LEU A 146
LEU A 280
TYR A 279
LEU A 133
 None
 1.23A 1hk2A-3talA:
undetectable		 1hk2A-3talA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 TYR A 294
LEU A 129
LEU A 280
TYR A 279
GLU A 102
 None
None
None
None
GOL  A 454 (-4.0A)
 1.36A 1mmkA-3talA:
undetectable		 1mmkA-3talA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 8 PHE A 347
TYR A 276
LEU A 280
ASP A 284
 None
 1.09A 1rmtD-3talA:
undetectable		 1rmtD-3talA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 LEU A 292
LEU A 129
GLU A 102
SER A 132
ALA A  71
 None
None
GOL  A 454 (-4.0A)
None
None
 1.30A 2bm9B-3talA:
undetectable		 2bm9B-3talA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 LEU A 169
PHE A 165
HIS A 271
ILE A  96
ILE A 190
 None
 1.40A 2efjA-3talA:
undetectable		 2efjA-3talA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 7 PHE A 299
ILE A 362
THR A 307
GLY A 131
 None
 0.94A 2v0mB-3talA:
undetectable		 2v0mB-3talA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 ILE A  29
ALA A 316
ALA A 305
VAL A  23
ASN A  22
 None
 1.10A 3jb3A-3talA:
undetectable		 3jb3A-3talA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 7 TYR A 203
GLU A 159
LEU A 199
LYS A 198
 None
 0.81A 3k8mB-3talA:
undetectable		 3k8mB-3talA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 LEU A 428
ILE A  64
ALA A  85
THR A  62
ALA A 438
 None
 0.94A 3mdvB-3talA:
undetectable		 3mdvB-3talA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 LEU A 180
VAL A  50
GLY A  52
ALA A  69
SER A  68
 None
 1.26A 3pghA-3talA:
undetectable		 3pghA-3talA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_B_LYAB304_1
(FOLATE RECEPTOR BETA)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 ASP A 193
THR A 192
ARG A  98
GLY A  91
TYR A  82
 None
 1.24A 4kn2B-3talA:
0.0		 4kn2B-3talA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 6 LEU A 146
LEU A 352
PHE A 347
VAL A 138
 None
 0.83A 4udaA-3talA:
undetectable		 4udaA-3talA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 LEU A 133
ASN A 147
LEU A 166
PHE A 355
ILE A 277
 None
 1.33A 5dv4A-3talA:
undetectable		 5dv4A-3talA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 8 ASP A 268
LYS A  87
SER A  88
ASP A 264
 None
 1.20A 5t8sB-3talA:
undetectable		 5t8sB-3talA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 TYR A  65
ILE A  64
PHE A  66
THR A 103
LEU A 104
 None
 1.25A 6baaE-3talA:
0.0		 6baaE-3talA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 TYR A  65
ILE A  64
PHE A  66
THR A 103
LEU A 104
 None
 1.25A 6baaF-3talA:
0.0		 6baaF-3talA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 TYR A  65
ILE A  64
PHE A  66
THR A 103
LEU A 104
 None
 1.25A 6baaG-3talA:
0.0		 6baaG-3talA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		5 / 12 TYR A  65
ILE A  64
PHE A  66
THR A 103
LEU A 104
 None
 1.26A 6baaH-3talA:
0.0		 6baaH-3talA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA
(Pyrococcus
furiosus) 		4 / 8 ASP A 268
LYS A  87
SER A  88
ASP A 264
 None
 1.21A 6fcdA-3talA:
undetectable		 6fcdA-3talA:
9.85