SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ALA A 314
VAL A 309
TRP A 319
 None
 0.96A 1gmkA-3tatA:
undetectable
1gmkB-3tatA:
undetectable		 1gmkA-3tatA:
3.58
1gmkB-3tatA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ALA A 314
VAL A 309
TRP A 319
 None
 0.85A 1gmkC-3tatA:
undetectable
1gmkD-3tatA:
undetectable		 1gmkC-3tatA:
3.58
1gmkD-3tatA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A 162
ASP A 137
ASN A 171
 None
 0.75A 2bm9D-3tatA:
3.3		 2bm9D-3tatA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE A 147
LEU A 187
VAL A 186
SER A 253
LEU A 200
 None
 1.25A 2hc4A-3tatA:
undetectable		 2hc4A-3tatA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 TYR A 263
TYR A 225
CYH A 191
CYH A 192
 None
 1.40A 2xytG-3tatA:
0.0		 2xytG-3tatA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 TYR A 263
TYR A 225
CYH A 191
CYH A 192
 None
 1.37A 2xytH-3tatA:
0.0		 2xytH-3tatA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 374
MET A  21
THR A  19
LEU A  18
 None
 1.36A 3ag1J-3tatA:
undetectable		 3ag1J-3tatA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 374
MET A  21
THR A  19
LEU A  18
 None
 1.37A 3ag2J-3tatA:
undetectable		 3ag2J-3tatA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 374
MET A  21
THR A  19
LEU A  18
 None
 1.36A 3ag4J-3tatA:
undetectable		 3ag4J-3tatA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 248
VAL A 272
ARG A  99
 None
 0.86A 3b0wB-3tatA:
undetectable		 3b0wB-3tatA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 PRO A  93
PHE A  88
ALA A 244
 None
 0.67A 3itaD-3tatA:
undetectable		 3itaD-3tatA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 ASP A 236
GLY A 231
ALA A 230
ILE A 330
 None
 0.73A 3t3cA-3tatA:
undetectable		 3t3cA-3tatA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A 281
ARG A 282
GLY A 285
ARG A  99
ASP A 276
 None
 1.30A 3tkaA-3tatA:
4.2		 3tkaA-3tatA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 ALA A 367
VAL A 370
ASP A 371
LEU A  20
 None
 0.80A 4e7gA-3tatA:
undetectable		 4e7gA-3tatA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ASP A 222
ILE A 218
LEU A 187
HIS A 143
TRP A 140
 PLP  A 500 (-3.7A)
None
None
None
PLP  A 500 ( 4.1A)
 1.34A 4j03A-3tatA:
undetectable		 4j03A-3tatA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 SER A 255
ASP A 236
ASP A 222
ILE A 223
ILE A 259
 PLP  A 500 ( 4.0A)
None
PLP  A 500 (-3.7A)
None
None
 1.50A 4ktvC-3tatA:
undetectable
4ktvD-3tatA:
undetectable		 4ktvC-3tatA:
22.20
4ktvD-3tatA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 306
LEU A  87
LYS A 258
SER A 257
SER A 271
 None
None
PLP  A 500 ( 1.3A)
PLP  A 500 (-2.6A)
None
 1.12A 4ky8D-3tatA:
undetectable		 4ky8D-3tatA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 306
LEU A  87
LYS A 258
SER A 257
SER A 271
 None
None
PLP  A 500 ( 1.3A)
PLP  A 500 (-2.6A)
None
 1.12A 4ky8E-3tatA:
undetectable		 4ky8E-3tatA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A  47
GLY A 391
MET A 359
ILE A  37
 None
 0.87A 4qogA-3tatA:
3.0
4qogB-3tatA:
3.0		 4qogA-3tatA:
20.29
4qogB-3tatA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A 197
ALA A 390
ILE A 330
MET A 333
LEU A 337
 None
 1.06A 4xumB-3tatA:
undetectable		 4xumB-3tatA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 284
LEU A  95
ILE A 240
GLU A  74
LEU A  87
 None
 1.21A 5ienB-3tatA:
undetectable		 5ienB-3tatA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 374
MET A  21
THR A  19
LEU A  18
 None
 1.27A 5x1bW-3tatA:
undetectable		 5x1bW-3tatA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 374
MET A  21
THR A  19
LEU A  18
 None
 1.35A 5x1fW-3tatA:
undetectable		 5x1fW-3tatA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 VAL A 133
LEU A 251
GLY A 151
GLY A 115
 None
 0.77A 6eu9D-3tatA:
undetectable		 6eu9D-3tatA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ASP A 222
ILE A 223
ILE A 259
SER A 255
ASP A 236
 PLP  A 500 (-3.7A)
None
None
PLP  A 500 ( 4.0A)
None
 1.44A 6fbpA-3tatA:
undetectable
6fbpB-3tatA:
undetectable		 6fbpA-3tatA:
13.01
6fbpB-3tatA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3tat TYROSINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 374
MET A  21
THR A  19
LEU A  18
 None
 1.31A 6nknJ-3tatA:
undetectable		 6nknJ-3tatA:
8.82