SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 8 GLY A 176
PHE A 175
LEU A 220
ARG A 165
 None
 0.70A 1d0vA-3tavA:
undetectable		 1d0vA-3tavA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 8 GLY A 176
PHE A 175
LEU A 220
ARG A 165
 None
 0.68A 1jhaA-3tavA:
undetectable		 1jhaA-3tavA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 163
GLY A 176
PHE A 175
LEU A 220
ARG A 165
 None
 1.00A 1jhrA-3tavA:
undetectable		 1jhrA-3tavA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 163
GLY A 176
PHE A 175
LEU A 220
ARG A 165
 None
 1.06A 1jhyA-3tavA:
undetectable		 1jhyA-3tavA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 163
GLY A 176
PHE A 175
LEU A 220
ARG A 165
 None
 1.01A 1l4nA-3tavA:
undetectable		 1l4nA-3tavA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 12 SER A 242
ASP A  82
ASP A 240
ARG A 228
THR A 224
 None
 1.49A 1s14A-3tavA:
undetectable		 1s14A-3tavA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  31
GLY A 114
GLY A 106
ILE A  28
ILE A 186
 None
 1.14A 1x1aA-3tavA:
undetectable		 1x1aA-3tavA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 7 TYR A  69
CYH A  77
HIS A  86
HIS A 191
TRP A 234
 LMR  A 271 ( 4.9A)
LMR  A 271 (-3.6A)
LMR  A 271 (-3.9A)
LMR  A 271 (-4.4A)
None
 0.45A 1yvmA-3tavA:
36.9		 1yvmA-3tavA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 7 TYR A  69
GLU A 217
HIS A 184
GLY A 183
 LMR  A 271 ( 4.9A)
MG  A 266 (-2.7A)
MG  A 266 (-3.4A)
None
 1.06A 2ha4B-3tavA:
undetectable		 2ha4B-3tavA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 5 GLN A 170
PHE A 171
PHE A 175
GLY A 163
 None
 1.37A 2qmzA-3tavA:
undetectable
2qmzB-3tavA:
undetectable		 2qmzA-3tavA:
21.68
2qmzB-3tavA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 7 THR A 154
GLY A 200
LEU A   4
PHE A   5
 None
 0.84A 2vl2B-3tavA:
undetectable		 2vl2B-3tavA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A 146
ILE A 144
GLY A 143
ILE A 160
HIS A 249
 None
 1.42A 2zm9A-3tavA:
undetectable		 2zm9A-3tavA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gB-3tavA:
undetectable		 3j6gB-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gD-3tavA:
undetectable		 3j6gD-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gF-3tavA:
undetectable		 3j6gF-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gH-3tavA:
undetectable		 3j6gH-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gJ-3tavA:
undetectable		 3j6gJ-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gL-3tavA:
undetectable		 3j6gL-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gN-3tavA:
undetectable		 3j6gN-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gP-3tavA:
undetectable		 3j6gP-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  52
LEU A  33
PHE A 120
GLN A  83
LEU A  95
 None
 1.43A 3j6gR-3tavA:
undetectable		 3j6gR-3tavA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 184
GLY A 185
ALA A 146
GLY A 143
ASN A 151
 MG  A 266 (-3.4A)
None
None
None
None
 1.21A 3v3oA-3tavA:
undetectable		 3v3oA-3tavA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 7 ARG A 264
GLY A  30
VAL A  29
SER A 116
 None
 1.00A 4a3uB-3tavA:
undetectable		 4a3uB-3tavA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 163
GLY A 176
PHE A 175
LEU A 220
ARG A 165
 None
 0.96A 4kqiA-3tavA:
undetectable		 4kqiA-3tavA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 114
GLY A 106
THR A 250
LEU A 261
GLY A 187
 None
 0.98A 4n48A-3tavA:
undetectable		 4n48A-3tavA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 114
GLY A 106
THR A 250
LEU A 261
GLY A 187
 None
 1.02A 4n48B-3tavA:
undetectable		 4n48B-3tavA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		3 / 3 ASP A  50
ARG A  58
PRO A  64
 None
 1.00A 4wanC-3tavA:
undetectable		 4wanC-3tavA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 5 VAL A 237
TYR A  69
ILE A 108
THR A 250
 None
LMR  A 271 ( 4.9A)
None
None
 1.22A 4ze1A-3tavA:
undetectable		 4ze1A-3tavA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 11 SER A 128
ALA A 121
ASP A  82
THR A 238
GLY A 241
 None
 1.44A 4zjoD-3tavA:
undetectable		 4zjoD-3tavA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 7 GLY A 183
HIS A 184
ASP A 115
HIS A  86
 None
MG  A 266 (-3.4A)
MG  A 269 ( 2.1A)
LMR  A 271 (-3.9A)
 0.78A 5nnwD-3tavA:
undetectable		 5nnwD-3tavA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		4 / 7 GLY A 183
HIS A 184
ASP A 115
HIS A  86
 None
MG  A 266 (-3.4A)
MG  A 269 ( 2.1A)
LMR  A 271 (-3.9A)
 0.77A 5no9D-3tavA:
undetectable		 5no9D-3tavA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3tav METHIONINE
AMINOPEPTIDASE
(Mycobacteroides
abscessus) 		5 / 11 LEU A 138
GLY A 143
ARG A 165
THR A 164
ALA A 167
 None
 1.05A 5o96A-3tavA:
undetectable
5o96B-3tavA:
undetectable		 5o96A-3tavA:
23.55
5o96B-3tavA:
23.55