SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		3 / 3 GLN A  60
ILE A 152
HIS A  34
 None
 0.70A 1fm9A-3tb4A:
undetectable		 1fm9A-3tb4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		3 / 3 GLN A  60
ILE A 152
HIS A  34
 None
 0.72A 1k74A-3tb4A:
undetectable		 1k74A-3tb4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		6 / 12 LEU A  15
GLY A 170
GLY A 172
VAL A 146
LEU A  11
LEU A  54
 None
 1.40A 1mx1D-3tb4A:
undetectable		 1mx1D-3tb4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 LEU A  61
GLY A 170
GLY A 172
ILE A  24
VAL A 168
 None
 0.98A 1v2xA-3tb4A:
undetectable		 1v2xA-3tb4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ILE A 188
LEU A 185
HIS A 149
ALA A 156
LEU A  54
 None
None
PGE  A 502 (-3.4A)
None
None
 1.14A 2a58A-3tb4A:
3.7
2a58B-3tb4A:
3.8		 2a58A-3tb4A:
21.30
2a58B-3tb4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ILE A 188
LEU A 185
HIS A 149
ALA A 156
LEU A  54
 None
None
PGE  A 502 (-3.4A)
None
None
 1.13A 2a58B-3tb4A:
3.8
2a58C-3tb4A:
3.1		 2a58B-3tb4A:
21.30
2a58C-3tb4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ILE A 188
LEU A 185
HIS A 149
ALA A 156
LEU A  54
 None
None
PGE  A 502 (-3.4A)
None
None
 1.13A 2a58D-3tb4A:
3.8
2a58E-3tb4A:
3.8		 2a58D-3tb4A:
21.30
2a58E-3tb4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		4 / 7 ALA A 174
ASP A 175
GLY A 170
ILE A 169
 None
 0.85A 2fxdB-3tb4A:
undetectable		 2fxdB-3tb4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		4 / 8 ILE A 150
TRP A  93
PHE A  92
TYR A 121
 BOG  A 501 (-3.5A)
BOG  A 501 ( 2.7A)
None
BOG  A 501 (-4.1A)
 1.24A 3ccfB-3tb4A:
3.5		 3ccfB-3tb4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		4 / 8 ALA A 174
ASP A 175
GLY A 170
ILE A 169
 None
 0.75A 3el9A-3tb4A:
undetectable		 3el9A-3tb4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 11 ASP A  35
PHE A  40
TRP A  93
LYS A 118
TYR A 121
 None
BOG  A 501 (-4.5A)
BOG  A 501 ( 2.7A)
None
BOG  A 501 (-4.1A)
 0.81A 3r2jB-3tb4A:
19.3		 3r2jB-3tb4A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ASP A  35
PHE A  40
TRP A  93
LYS A 118
TYR A 121
 None
BOG  A 501 (-4.5A)
BOG  A 501 ( 2.7A)
None
BOG  A 501 (-4.1A)
 0.84A 3r2jC-3tb4A:
19.5		 3r2jC-3tb4A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 11 ASP A  35
PHE A  40
TRP A  93
LYS A 118
TYR A 121
 None
BOG  A 501 (-4.5A)
BOG  A 501 ( 2.7A)
None
BOG  A 501 (-4.1A)
 0.81A 3r2jD-3tb4A:
19.4		 3r2jD-3tb4A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 LEU A  32
VAL A  73
ALA A 123
LEU A 130
LEU A 133
 None
 1.20A 4i1rA-3tb4A:
3.3		 4i1rA-3tb4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ILE A 142
ILE A 188
LEU A  15
PRO A  16
ILE A 169
 None
 1.07A 4m2xE-3tb4A:
undetectable		 4m2xE-3tb4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 10 GLY A 145
ASP A 175
TYR A 147
ILE A  51
LEU A  54
 None
None
BOG  A 501 (-4.1A)
None
None
 1.22A 4xj7A-3tb4A:
3.3
4xj7B-3tb4A:
3.3		 4xj7A-3tb4A:
23.37
4xj7B-3tb4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		4 / 6 CYH A 202
GLN A 199
ILE A 169
ASP A 171
 None
 1.16A 4z4cA-3tb4A:
3.7		 4z4cA-3tb4A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		4 / 6 CYH A 202
GLN A 199
ILE A 169
ASP A 171
 None
 1.20A 4z4dA-3tb4A:
3.6		 4z4dA-3tb4A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		5 / 12 ALA A 148
GLY A 145
PHE A  40
GLY A 170
GLY A 151
 None
None
BOG  A 501 (-4.5A)
None
CA  A 505 (-3.5A)
 1.02A 5gwxA-3tb4A:
3.5		 5gwxA-3tb4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		3 / 3 ILE A  58
ILE A 142
MET A  36
 None
 0.67A 5i9yA-3tb4A:
undetectable		 5i9yA-3tb4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		4 / 8 ILE A   6
PRO A   4
ALA A  48
ILE A  51
 BOG  A 501 ( 4.4A)
None
None
None
 0.73A 5mvmA-3tb4A:
undetectable
5mvmB-3tb4A:
undetectable		 5mvmA-3tb4A:
14.35
5mvmB-3tb4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE
(Vibrio
cholerae) 		4 / 6 CYH A 202
GLN A 199
ILE A 169
ASP A 171
 None
 1.21A 6cbdA-3tb4A:
3.6		 6cbdA-3tb4A:
14.70