SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		3 / 3 GLU A  41
TRP A  38
LYS A 127
 None
 1.38A 1qu2A-3tb5A:
undetectable		 1qu2A-3tb5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		6 / 10 ALA A 137
ILE A 143
GLY A 144
GLY A 147
ILE A 150
ILE A 198
 None
 1.19A 1sdvA-3tb5A:
undetectable		 1sdvA-3tb5A:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 7 TYR A  60
TYR A  63
CYH A  68
HIS A  77
 CIT  A 265 (-4.0A)
None
CIT  A 265 ( 4.5A)
CIT  A 265 (-3.4A)
 0.59A 1yvmA-3tb5A:
40.4		 1yvmA-3tb5A:
38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 7 TYR A  63
CYH A  68
HIS A  77
TRP A 218
 None
CIT  A 265 ( 4.5A)
CIT  A 265 (-3.4A)
None
 0.49A 1yvmA-3tb5A:
40.4		 1yvmA-3tb5A:
38.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 7 ARG A  81
TYR A  63
ASP A 214
GLU A  74
 None
 1.06A 2qebA-3tb5A:
undetectable		 2qebA-3tb5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 7 ARG A  81
TYR A  63
ASP A 214
GLU A  74
 None
 1.05A 2qebB-3tb5A:
undetectable		 2qebB-3tb5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 8 SER A 109
VAL A 112
TYR A 231
ASN A  72
 None
 1.19A 2wekB-3tb5A:
undetectable		 2wekB-3tb5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		5 / 11 ILE A  91
LEU A  85
ILE A  35
VAL A  44
LEU A  27
 None
 1.19A 3a51A-3tb5A:
undetectable		 3a51A-3tb5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		5 / 12 ALA A 236
GLY A 195
LEU A 192
ASP A  14
GLY A 241
 None
 1.09A 3g2oB-3tb5A:
undetectable		 3g2oB-3tb5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 5 ASP A 105
GLU A 176
GLY A 169
GLU A 201
 CIT  A 265 (-4.2A)
None
None
CIT  A 265 (-2.8A)
 1.22A 3w9tA-3tb5A:
undetectable		 3w9tA-3tb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 5 ASP A 105
GLU A 176
GLY A 169
GLU A 201
 CIT  A 265 (-4.2A)
None
None
CIT  A 265 (-2.8A)
 1.23A 3w9tC-3tb5A:
undetectable		 3w9tC-3tb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 5 ASP A 105
GLU A 176
GLY A 169
GLU A 201
 CIT  A 265 (-4.2A)
None
None
CIT  A 265 (-2.8A)
 1.22A 3w9tD-3tb5A:
undetectable		 3w9tD-3tb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 5 ASP A 105
GLU A 176
GLY A 169
GLU A 201
 CIT  A 265 (-4.2A)
None
None
CIT  A 265 (-2.8A)
 1.23A 3w9tG-3tb5A:
undetectable		 3w9tG-3tb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		3 / 3 MET A  95
MET A 203
TYR A 110
 None
 1.39A 4p6xI-3tb5A:
undetectable		 4p6xI-3tb5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 7 LEU A 122
LEU A  90
THR A 222
THR A 206
 None
 0.88A 4z90A-3tb5A:
undetectable
4z90B-3tb5A:
undetectable
4z90C-3tb5A:
undetectable
4z90D-3tb5A:
undetectable
4z90E-3tb5A:
undetectable		 4z90A-3tb5A:
20.24
4z90B-3tb5A:
20.24
4z90C-3tb5A:
20.24
4z90D-3tb5A:
20.24
4z90E-3tb5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 7 GLY A 167
HIS A 168
ASP A 105
HIS A  77
 None
CIT  A 265 (-3.8A)
CIT  A 265 (-4.2A)
CIT  A 265 (-3.4A)
 1.00A 5nnwD-3tb5A:
undetectable		 5nnwD-3tb5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		4 / 7 GLY A 167
HIS A 168
ASP A 105
HIS A  77
 None
CIT  A 265 (-3.8A)
CIT  A 265 (-4.2A)
CIT  A 265 (-3.4A)
 1.03A 5no9D-3tb5A:
undetectable		 5no9D-3tb5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		5 / 12 HIS A 233
ILE A  31
LEU A 252
LEU A 130
TYR A 131
 None
 1.42A 5ycpA-3tb5A:
undetectable		 5ycpA-3tb5A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 3tb5 METHIONINE
AMINOPEPTIDASE
(Enterococcus
faecalis) 		5 / 12 LEU A  27
VAL A  93
HIS A  51
SER A  50
GLY A  53
 None
 1.33A 6mn8A-3tb5A:
2.2		 6mn8A-3tb5A:
20.47