SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tbb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.64A 1oe1A-3tbbA:
21.5		 1oe1A-3tbbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.63A 1oe2A-3tbbA:
13.0		 1oe2A-3tbbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.66A 1oe3A-3tbbA:
21.5		 1oe3A-3tbbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 SER A 115
ARG A 123
HIS A  99
HIS A 151
 None
None
CU  A  12 ( 3.3A)
CU  A  12 (-3.4A)
 0.91A 1s19A-3tbbA:
undetectable		 1s19A-3tbbA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.53A 2fqdA-3tbbA:
undetectable		 2fqdA-3tbbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.50A 2fqeA-3tbbA:
17.8		 2fqeA-3tbbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.52A 2fqfA-3tbbA:
17.8		 2fqfA-3tbbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.53A 2fqgA-3tbbA:
undetectable		 2fqgA-3tbbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		5 / 12 ILE A 188
ALA A 208
VAL A 299
PHE A 228
HIS A 229
 None
None
None
None
CU  A   7 ( 3.2A)
 1.07A 2qo4A-3tbbA:
undetectable		 2qo4A-3tbbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		5 / 12 ILE A 188
ALA A 208
VAL A 299
PHE A 228
HIS A 229
 None
None
None
None
CU  A   7 ( 3.2A)
 1.05A 2qo6A-3tbbA:
undetectable		 2qo6A-3tbbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		3 / 3 TRP A 235
GLN A 267
TRP A 279
 None
 1.06A 2vqyA-3tbbA:
undetectable		 2vqyA-3tbbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.62A 2xxgA-3tbbA:
6.4		 2xxgA-3tbbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.65A 2xxgC-3tbbA:
6.4		 2xxgC-3tbbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		5 / 10 PHE A 228
VAL A 252
ALA A 236
PHE A 266
PHE A 216
 None
 1.13A 3a3yA-3tbbA:
undetectable		 3a3yA-3tbbA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		3 / 3 HIS A 282
HIS A 229
HIS A 231
 CU  A   8 ( 3.3A)
CU  A   7 ( 3.2A)
CU  A   8 (-3.3A)
 0.83A 3mihA-3tbbA:
undetectable		 3mihA-3tbbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		3 / 3 HIS A 282
HIS A 231
MET A 280
 CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
CU  A   8 ( 4.6A)
 0.68A 3mihA-3tbbA:
undetectable		 3mihA-3tbbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.52A 4ef3A-3tbbA:
17.7		 4ef3A-3tbbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 ILE A  84
LEU A  73
HIS A 149
VAL A  98
 None
 1.17A 5jmnB-3tbbA:
undetectable		 5jmnB-3tbbA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		5 / 12 GLY A  59
VAL A 189
THR A 161
GLY A 162
GLY A 163
 None
 0.95A 5koxA-3tbbA:
undetectable		 5koxA-3tbbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mhwA-3tbbA:
11.6		 5mhwA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.90A 5mhxA-3tbbA:
10.9		 5mhxA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mhyA-3tbbA:
11.6		 5mhyA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mhzA-3tbbA:
11.6		 5mhzA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mi1A-3tbbA:
11.6		 5mi1A-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mi2A-3tbbA:
10.8		 5mi2A-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5miaA-3tbbA:
11.6		 5miaA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mibA-3tbbA:
11.5		 5mibA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5micA-3tbbA:
10.9		 5micA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5midA-3tbbA:
11.6		 5midA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mieA-3tbbA:
11.0		 5mieA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 5 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.90A 5migA-3tbbA:
11.5		 5migA-3tbbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 6 GLN A 267
VAL A 214
ALA A 208
THR A 209
 None
 0.95A 6cduB-3tbbA:
undetectable
6cduC-3tbbA:
undetectable		 6cduB-3tbbA:
21.64
6cduC-3tbbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		4 / 7 GLN A 267
VAL A 214
ALA A 208
THR A 209
 None
 0.96A 6cduC-3tbbA:
undetectable
6cduD-3tbbA:
undetectable		 6cduC-3tbbA:
21.64
6cduD-3tbbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3tbb SMALL LACCASE,
OXIDOREDUCTASE
(Streptomyces
viridosporus) 		5 / 11 HIS A 130
ASP A 102
GLY A 100
SER A 144
ALA A 142
 None
None
None
None
PO4  A   4 (-3.6A)
 1.11A 6ieyA-3tbbA:
undetectable
6ieyB-3tbbA:
undetectable		 6ieyA-3tbbA:
22.76
6ieyB-3tbbA:
22.76