SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 5 PHE A 574
TYR A 436
LEU A 428
ASP A 573
 None
 1.32A 1dz6A-3tbfA:
undetectable		 1dz6A-3tbfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 9 LEU A 419
LEU A 273
GLU A 438
ILE A 269
PHE A 391
 None
 1.36A 1gx8A-3tbfA:
undetectable		 1gx8A-3tbfA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 9 LEU A 584
LEU A 586
LEU A 587
ILE A 457
PHE A 549
 None
 1.19A 2f78A-3tbfA:
0.8		 2f78A-3tbfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		3 / 3 SER A 588
THR A 408
GLN A 261
 None
 0.79A 2fk8A-3tbfA:
2.1		 2fk8A-3tbfA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 12 ALA A 413
LEU A 414
ALA A 415
GLN A 585
ILE A 481
 None
 1.17A 2jjpA-3tbfA:
undetectable		 2jjpA-3tbfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 8 ASP A 454
HIS A 590
LEU A 255
HIS A 252
 None
 1.06A 2q0iA-3tbfA:
undetectable		 2q0iA-3tbfA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 4 VAL A 412
ARG A 444
ILE A 582
THR A 393
 None
 1.39A 3cl9A-3tbfA:
undetectable		 3cl9A-3tbfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 6 VAL A 520
ILE A 457
ILE A 547
LEU A 548
 None
 0.79A 3hegA-3tbfA:
undetectable		 3hegA-3tbfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 8 GLY A 303
CYH A 374
PHE A 391
GLY A 309
 None
 0.97A 3ko0O-3tbfA:
undetectable
3ko0Q-3tbfA:
undetectable		 3ko0O-3tbfA:
15.08
3ko0Q-3tbfA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 7 PHE A 549
VAL A 520
ILE A 547
SER A 588
 None
 0.97A 3pglA-3tbfA:
undetectable		 3pglA-3tbfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 11 TYR A 319
ALA A 312
ILE A 316
THR A 581
PRO A 577
 None
 1.40A 3qelA-3tbfA:
2.9
3qelB-3tbfA:
2.7		 3qelA-3tbfA:
23.29
3qelB-3tbfA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 9 ASP A 458
ILE A 457
ILE A 495
ILE A 547
ILE A 460
 None
 1.00A 3s45A-3tbfA:
undetectable		 3s45A-3tbfA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 12 SER A 272
ILE A 278
PHE A 291
ALA A 413
ALA A 390
 None
 1.34A 3ua1A-3tbfA:
undetectable		 3ua1A-3tbfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 7 PRO A 262
VAL A 447
MET A 448
ALA A 450
 None
 1.09A 4lb2A-3tbfA:
undetectable		 4lb2A-3tbfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 12 TYR A 319
ALA A 312
ILE A 316
THR A 581
PRO A 577
 None
 1.40A 5ewjC-3tbfA:
undetectable
5ewjD-3tbfA:
2.6		 5ewjC-3tbfA:
23.06
5ewjD-3tbfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 12 ILE A 481
PHE A 407
ALA A 415
THR A 418
ILE A 316
 None
 1.09A 5vceA-3tbfA:
undetectable		 5vceA-3tbfA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		5 / 10 GLN A 261
SER A 461
VAL A 520
PHE A 407
PHE A 472
 None
 1.29A 6behA-3tbfA:
0.0
6behB-3tbfA:
0.0
6behC-3tbfA:
0.0		 6behA-3tbfA:
19.79
6behB-3tbfA:
19.79
6behC-3tbfA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Francisella
tularensis) 		4 / 6 THR A 581
LEU A 584
THR A 311
LEU A 487
 None
 0.96A 6mvxA-3tbfA:
0.9
6mvxB-3tbfA:
undetectable
6mvxC-3tbfA:
undetectable		 6mvxA-3tbfA:
21.45
6mvxB-3tbfA:
21.45
6mvxC-3tbfA:
21.45