SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 9 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
 None
None
LLP  A  51 ( 4.2A)
None
None
 1.10A 1e7aB-3tbhA:
undetectable		 1e7aB-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ALA A 256
GLY A 184
GLY A 275
GLY A 276
LEU A 218
 None
 0.82A 1eizA-3tbhA:
2.5		 1eizA-3tbhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ALA A 256
GLY A 184
GLY A 275
GLY A 276
LEU A 218
 None
 0.82A 1ej0A-3tbhA:
3.0		 1ej0A-3tbhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 GLY A  95
SER A  14
ILE A  15
LEU A  90
GLY A  91
 None
 0.84A 1uakA-3tbhA:
undetectable		 1uakA-3tbhA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 GLU A 211
ALA A 209
PRO A 212
ALA A 281
ASP A 246
 None
 1.34A 2admA-3tbhA:
2.5		 2admA-3tbhA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
 None
None
LLP  A  51 ( 4.2A)
None
None
 1.16A 2bxeA-3tbhA:
undetectable		 2bxeA-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
 None
None
LLP  A  51 ( 4.2A)
None
None
 1.11A 2bxeB-3tbhA:
undetectable		 2bxeB-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 HIS A 162
VAL A 185
GLY A 186
ILE A 182
ALA A 183
 None
LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.5A)
None
None
 1.18A 2yy8A-3tbhA:
2.9
2yy8B-3tbhA:
undetectable		 2yy8A-3tbhA:
20.59
2yy8B-3tbhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 GLY A  95
SER A  14
ILE A  15
LEU A  90
GLY A  91
 None
 0.82A 3axzA-3tbhA:
undetectable		 3axzA-3tbhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 7 ASP A 267
SER A 266
GLU A 258
ASP A 255
 None
 1.30A 3bc9A-3tbhA:
undetectable		 3bc9A-3tbhA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ALA A  24
GLY A 275
THR A 190
VAL A 194
THR A 166
 None
None
LLP  A  51 ( 3.7A)
None
None
 1.14A 3c6gB-3tbhA:
undetectable		 3c6gB-3tbhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ALA A 282
VAL A 269
THR A 174
VAL A 178
THR A 295
 None
 0.99A 3c6gB-3tbhA:
undetectable		 3c6gB-3tbhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ALA A 282
VAL A 269
THR A 174
VAL A 178
THR A 295
 None
 0.97A 3czhA-3tbhA:
undetectable		 3czhA-3tbhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ALA A 282
VAL A 269
THR A 174
VAL A 178
THR A 295
 None
 0.98A 3czhB-3tbhA:
undetectable		 3czhB-3tbhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		3 / 3 THR A 192
LYS A  67
GLU A 163
 None
 0.98A 3ijdB-3tbhA:
undetectable		 3ijdB-3tbhA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 GLY A 276
GLY A 272
LEU A 263
ALA A 277
ASN A 278
 None
 1.17A 3kkzA-3tbhA:
3.1		 3kkzA-3tbhA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 GLU A 247
ASP A 246
LEU A 249
ILE A 182
CYH A 180
 None
 1.32A 3ko0C-3tbhA:
undetectable
3ko0D-3tbhA:
undetectable
3ko0E-3tbhA:
undetectable
3ko0F-3tbhA:
undetectable		 3ko0C-3tbhA:
13.77
3ko0D-3tbhA:
13.77
3ko0E-3tbhA:
13.77
3ko0F-3tbhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 LEU A 249
ILE A 182
CYH A 180
GLU A 247
ASP A 246
 None
 1.31A 3ko0C-3tbhA:
undetectable
3ko0D-3tbhA:
undetectable
3ko0E-3tbhA:
undetectable
3ko0F-3tbhA:
undetectable		 3ko0C-3tbhA:
13.77
3ko0D-3tbhA:
13.77
3ko0E-3tbhA:
13.77
3ko0F-3tbhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 GLU A 247
ASP A 246
LEU A 249
ILE A 182
CYH A 180
 None
 1.29A 3ko0K-3tbhA:
0.0
3ko0L-3tbhA:
undetectable
3ko0M-3tbhA:
0.0
3ko0N-3tbhA:
undetectable		 3ko0K-3tbhA:
13.77
3ko0L-3tbhA:
13.77
3ko0M-3tbhA:
13.77
3ko0N-3tbhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 GLY A 188
VAL A 236
ALA A 183
GLY A 184
ILE A 245
 LLP  A  51 ( 3.4A)
None
None
None
None
 1.08A 3ku1G-3tbhA:
3.3		 3ku1G-3tbhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 5 GLY A 232
GLU A 211
GLY A 234
PRO A 212
 None
 1.10A 3onnA-3tbhA:
2.8		 3onnA-3tbhA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ILE A 231
GLY A 253
ALA A 252
THR A 213
VAL A 210
 None
 0.89A 3rukB-3tbhA:
undetectable		 3rukB-3tbhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ASP A 246
GLY A 193
ALA A 195
PHE A 181
ALA A 183
 None
 1.03A 3sudA-3tbhA:
undetectable		 3sudA-3tbhA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ASP A 246
GLY A 193
ALA A 195
PHE A 181
ALA A 183
 None
 1.00A 3sudC-3tbhA:
undetectable		 3sudC-3tbhA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 THR A 165
GLY A 167
GLY A 193
HIS A 162
GLN A 173
 None
 1.26A 3tkaA-3tbhA:
2.6		 3tkaA-3tbhA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 4 ASN A 158
ALA A 159
GLY A 189
THR A 190
 LLP  A  51 ( 4.9A)
None
LLP  A  51 ( 3.8A)
LLP  A  51 ( 3.7A)
 1.38A 4bboC-3tbhA:
undetectable		 4bboC-3tbhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ILE A 231
GLY A 272
GLY A 275
ILE A 257
ALA A 256
 None
 1.12A 4kicB-3tbhA:
2.5		 4kicB-3tbhA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		3 / 3 GLY A 129
GLU A 104
THR A 124
 None
 0.58A 4kouA-3tbhA:
undetectable		 4kouA-3tbhA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ILE A 231
GLY A 253
ALA A 252
THR A 213
VAL A 210
 None
 0.83A 4nkvA-3tbhA:
undetectable		 4nkvA-3tbhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ILE A 231
GLY A 253
ALA A 252
THR A 213
VAL A 210
 None
 0.83A 4nkvB-3tbhA:
undetectable		 4nkvB-3tbhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ILE A 231
GLY A 253
ALA A 252
THR A 213
VAL A 210
 None
 0.81A 4nkxA-3tbhA:
undetectable		 4nkxA-3tbhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 9 THR A 259
ILE A 228
VAL A 208
LEU A 249
ILE A 285
 None
 1.22A 4r38C-3tbhA:
undetectable		 4r38C-3tbhA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 4 GLU A 169
GLY A 167
HIS A 162
ARG A  53
 None
 1.20A 4r82A-3tbhA:
undetectable
4r82B-3tbhA:
undetectable		 4r82A-3tbhA:
21.71
4r82B-3tbhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 GLY A  95
SER A  14
ILE A  15
LEU A  90
GLY A  91
 None
 0.85A 4yvgA-3tbhA:
undetectable		 4yvgA-3tbhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 ALA A 256
GLY A 272
VAL A 210
LEU A 249
THR A 298
 None
 1.08A 4zmeA-3tbhA:
undetectable		 4zmeA-3tbhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		6 / 11 THR A 298
ALA A 281
VAL A 210
GLY A 275
GLY A 276
ALA A 277
 None
 1.28A 5lf7K-3tbhA:
undetectable
5lf7L-3tbhA:
undetectable		 5lf7K-3tbhA:
22.94
5lf7L-3tbhA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		6 / 11 THR A 298
ALA A 281
VAL A 210
GLY A 275
GLY A 276
ALA A 277
 None
 1.28A 5lf7Y-3tbhA:
undetectable
5lf7Z-3tbhA:
undetectable		 5lf7Y-3tbhA:
22.94
5lf7Z-3tbhA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 VAL A 210
GLU A 247
LEU A  27
ALA A 281
ARG A 288
 None
 1.27A 5nd3B-3tbhA:
undetectable		 5nd3B-3tbhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 VAL A 210
GLU A 247
LEU A  39
ALA A 281
ARG A 288
 None
 1.19A 5nd3B-3tbhA:
undetectable		 5nd3B-3tbhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 VAL A 210
GLU A 247
LEU A  39
ALA A 281
ARG A 288
 None
 1.17A 5nd7B-3tbhA:
undetectable		 5nd7B-3tbhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		3 / 3 MET A 102
GLU A 109
ARG A 111
 None
 1.10A 5tjzA-3tbhA:
undetectable		 5tjzA-3tbhA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 LEU A 191
GLY A 188
GLY A 189
VAL A 239
LEU A 218
 None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 3.8A)
None
None
 1.19A 5uc1A-3tbhA:
undetectable		 5uc1A-3tbhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 4 GLU A 287
THR A  33
THR A 298
LEU A 263
 None
 1.36A 5v96A-3tbhA:
5.5		 5v96A-3tbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 4 GLU A 287
THR A  33
THR A 298
LEU A 263
 None
 1.36A 5v96B-3tbhA:
5.5		 5v96B-3tbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 4 GLU A 287
THR A  33
THR A 298
LEU A 263
 None
 1.34A 5v96C-3tbhA:
5.5		 5v96C-3tbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 4 GLU A 287
THR A  33
THR A 298
LEU A 263
 None
 1.33A 5v96D-3tbhA:
5.5		 5v96D-3tbhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 GLY A  95
SER A  14
ILE A  15
LEU A  90
GLY A  91
 None
 0.85A 5wyqB-3tbhA:
undetectable		 5wyqB-3tbhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 VAL A 185
GLY A 186
SER A 274
ALA A 209
LEU A 191
 LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.5A)
LLP  A  51 ( 2.6A)
None
None
 1.21A 5x6yC-3tbhA:
3.0		 5x6yC-3tbhA:
17.43