SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tbi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RV7_B_AB1B1001_1 (PROTEASE)	3tbi	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 11	ALA B 861 ILE B 870 VAL B 857 ALA B 875 VAL B 877	None	1.15A	1rv7A-3tbiB: undetectable 1rv7B-3tbiB: undetectable	1rv7A-3tbiB: 16.67 1rv7B-3tbiB: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EBZ_B_017B201_1 (PROTEASE)	3tbi	RNA POLYMERASE-ASSOCIATE D PROTEIN GP33 (Escherichia virus T4)	5 / 11	ALA A 58 ILE A 81 ILE A 68 ILE A 43 ILE A 44	None	1.13A	3ebzA-3tbiA: undetectable	3ebzA-3tbiA: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AFG_C_QMRC1214_1 (CAPITELLA TELETA ACHBP)	3tbi	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	4 / 8	VAL B 887 CYH B 838 ILE B 854 ILE B 850	None	0.94A	4afgD-3tbiB: undetectable 4afgE-3tbiB: undetectable	4afgD-3tbiB: 20.54 4afgE-3tbiB: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FI4_B_DVAB8_0 (14-3-3 PROTEIN SIGMA PRO-SEP-LEU-PRO-DVA)	3tbi	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	4 / 5	SER B 916 VAL B 887 LYS B 886 PRO B 847	None	1.36A	6fi4A-3tbiB: 4.2 6fi4B-3tbiB: undetectable	6fi4A-3tbiB: 21.79 6fi4B-3tbiB: 5.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RV7_B_AB1B1001_1","PROTEASE;PROTEASE","3tbi","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"ALA B 861;ILE B 870;VAL B 857;ALA B 875;VAL B 877","None","1.15A","1rv7A-3tbiB:undetectable;1rv7B-3tbiB:undetectable","1rv7A-3tbiB:16.67;1rv7B-3tbiB:16.67"],["3EBZ_B_017B201_1","PROTEASE;PROTEASE","3tbi","RNA POLYMERASE-ASSOCIATED PROTEIN GP33","Escherichia virus T4",5,"ALA A  58;ILE A  81;ILE A  68;ILE A  43;ILE A  44","None","1.13A","3ebzA-3tbiA:undetectable","3ebzA-3tbiA:23.53"],["4AFG_C_QMRC1214_1","CAPITELLA TELETA ACHBP;CAPITELLA TELETA ACHBP;CAPITELLA TELETA ACHBP","3tbi","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",4,"VAL B 887;CYH B 838;ILE B 854;ILE B 850","None","0.94A","4afgD-3tbiB:undetectable;4afgE-3tbiB:undetectable","4afgD-3tbiB:20.54;4afgE-3tbiB:20.54"],["6FI4_B_DVAB8_0","14-3-3 PROTEIN SIGMA;PRO-SEP-LEU-PRO-DVA","3tbi","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",4,"SER B 916;VAL B 887;LYS B 886;PRO B 847","None","1.36A","6fi4A-3tbiB:4.2;6fi4B-3tbiB:undetectable","6fi4A-3tbiB:21.79;6fi4B-3tbiB:5.41"]]