SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 557
LEU A 640
ALA A 643
LEU A 644
 None
 0.93A 1hwiD-3tbkA:
undetectable		 1hwiD-3tbkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 TYR A 549
LEU A 486
LEU A 479
GLU A 586
 None
 1.07A 1i7zA-3tbkA:
undetectable		 1i7zA-3tbkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		3 / 3 THR A 507
GLU A 717
ASP A 614
 None
 0.70A 1nt2A-3tbkA:
3.7		 1nt2A-3tbkA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.73A 1p7lD-3tbkA:
undetectable		 1p7lD-3tbkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.75A 1p7lC-3tbkA:
undetectable		 1p7lC-3tbkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.71A 1rg9B-3tbkA:
undetectable		 1rg9B-3tbkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.72A 1rg9A-3tbkA:
undetectable		 1rg9A-3tbkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.72A 1rg9D-3tbkA:
undetectable		 1rg9D-3tbkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.74A 1rg9C-3tbkA:
undetectable		 1rg9C-3tbkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		3 / 3 LEU A 715
LEU A 741
SER A 461
 None
 0.58A 1tlmA-3tbkA:
undetectable		 1tlmA-3tbkA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 LYS A 611
LYS A 751
THR A 507
SER A 745
 None
 1.21A 1xr2B-3tbkA:
undetectable		 1xr2B-3tbkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 11 VAL A 407
ALA A 441
ALA A 265
ASP A 445
PRO A 254
 None
 1.27A 2admB-3tbkA:
2.1		 2admB-3tbkA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 7 VAL A 464
ARG A 462
LEU A 615
PHE A 740
 None
 1.14A 2f78B-3tbkA:
undetectable		 2f78B-3tbkA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 6 LEU A 435
GLN A 785
GLU A 788
ILE A 784
 None
 1.07A 2fcnA-3tbkA:
undetectable
2fcnB-3tbkA:
undetectable		 2fcnA-3tbkA:
12.44
2fcnB-3tbkA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 7 ARG A 444
ALA A 437
ASP A 436
GLY A 778
 None
 0.72A 2fxdB-3tbkA:
undetectable		 2fxdB-3tbkA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		3 / 3 SER A 412
THR A 442
PHE A 777
 None
None
EDO  A 795 ( 3.6A)
 0.75A 2x91A-3tbkA:
2.5		 2x91A-3tbkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 11 LEU A 633
ILE A 661
PRO A 659
ILE A 694
ILE A 696
 None
 1.05A 3ebzA-3tbkA:
undetectable		 3ebzA-3tbkA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 LEU A 347
ALA A 298
GLY A 327
ILE A 346
SER A 324
 None
 1.23A 3gyqA-3tbkA:
undetectable
3gyqB-3tbkA:
undetectable		 3gyqA-3tbkA:
17.99
3gyqB-3tbkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 11 LEU A 347
ALA A 298
GLY A 327
ILE A 346
SER A 324
 None
 1.20A 3gyqB-3tbkA:
undetectable		 3gyqB-3tbkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 PHE A 777
LEU A 431
ILE A 262
LEU A 435
ASP A 436
 EDO  A 795 ( 3.6A)
None
None
None
None
 0.85A 3ko0G-3tbkA:
undetectable
3ko0H-3tbkA:
undetectable
3ko0I-3tbkA:
undetectable
3ko0J-3tbkA:
undetectable		 3ko0G-3tbkA:
10.99
3ko0H-3tbkA:
10.99
3ko0I-3tbkA:
10.99
3ko0J-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 11 PHE A 777
LEU A 435
ASP A 436
LEU A 431
ILE A 262
 EDO  A 795 ( 3.6A)
None
None
None
None
 0.83A 3ko0A-3tbkA:
undetectable
3ko0B-3tbkA:
undetectable
3ko0I-3tbkA:
undetectable
3ko0J-3tbkA:
undetectable		 3ko0A-3tbkA:
10.99
3ko0B-3tbkA:
10.99
3ko0I-3tbkA:
10.99
3ko0J-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 LEU A 431
ILE A 262
LEU A 435
ASP A 436
PHE A 777
 None
None
None
None
EDO  A 795 ( 3.6A)
 0.78A 3ko0K-3tbkA:
undetectable
3ko0L-3tbkA:
undetectable
3ko0S-3tbkA:
undetectable
3ko0T-3tbkA:
undetectable		 3ko0K-3tbkA:
10.99
3ko0L-3tbkA:
10.99
3ko0S-3tbkA:
10.99
3ko0T-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 LEU A 431
ILE A 262
LEU A 435
ASP A 436
PHE A 777
 None
None
None
None
EDO  A 795 ( 3.6A)
 0.82A 3ko0M-3tbkA:
undetectable
3ko0N-3tbkA:
undetectable
3ko0O-3tbkA:
undetectable
3ko0P-3tbkA:
undetectable		 3ko0M-3tbkA:
10.99
3ko0N-3tbkA:
10.99
3ko0O-3tbkA:
10.99
3ko0P-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 PHE A 777
LEU A 435
ASP A 436
LEU A 431
ILE A 262
 EDO  A 795 ( 3.6A)
None
None
None
None
 0.84A 3ko0M-3tbkA:
undetectable
3ko0N-3tbkA:
undetectable
3ko0O-3tbkA:
undetectable
3ko0P-3tbkA:
undetectable		 3ko0M-3tbkA:
10.99
3ko0N-3tbkA:
10.99
3ko0O-3tbkA:
10.99
3ko0P-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 11 ALA A 265
ILE A 428
ALA A 441
THR A 261
VAL A 407
 None
 1.07A 3rukD-3tbkA:
undetectable		 3rukD-3tbkA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 ARG A 547
GLU A 511
TYR A 510
VAL A 517
HIS A 518
 None
 1.42A 3w2tA-3tbkA:
undetectable		 3w2tA-3tbkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.84A 4kttB-3tbkA:
undetectable		 4kttB-3tbkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.76A 4kttD-3tbkA:
undetectable		 4kttD-3tbkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 9 ALA A 643
ILE A 661
GLY A 660
ILE A 694
THR A 698
 None
 1.10A 4nptA-3tbkA:
undetectable		 4nptA-3tbkA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 10 THR A 378
ILE A 371
ASN A 260
LEU A 392
LEU A 364
 None
 1.36A 4r3aB-3tbkA:
undetectable		 4r3aB-3tbkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 6 LYS A 611
LEU A 742
GLU A 717
TYR A 716
 None
 1.38A 4z4cA-3tbkA:
undetectable		 4z4cA-3tbkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 5 LYS A 611
LEU A 742
GLU A 717
TYR A 716
 None
 1.37A 4z4dA-3tbkA:
0.9		 4z4dA-3tbkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 5 LYS A 611
LEU A 742
GLU A 717
TYR A 716
 None
 1.31A 4z4hA-3tbkA:
undetectable		 4z4hA-3tbkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 7 ILE A 278
LEU A 369
GLY A 258
LYS A 257
 None
 0.95A 4z69A-3tbkA:
3.3		 4z69A-3tbkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 GLY A 416
MET A 762
CYH A 264
THR A 410
LEU A 431
 None
 1.45A 5fhzD-3tbkA:
undetectable		 5fhzD-3tbkA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 4 CYH A 375
LEU A 435
LEU A 431
ALA A 434
 None
 1.05A 5hpuA-3tbkA:
undetectable
5hpuB-3tbkA:
undetectable		 5hpuA-3tbkA:
4.29
5hpuB-3tbkA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		4 / 8 GLU A 703
ASP A 706
ILE A 705
ILE A 632
 None
 0.75A 5t8sA-3tbkA:
undetectable		 5t8sA-3tbkA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 12 ARG A 547
GLU A 511
TYR A 510
VAL A 517
HIS A 518
 None
 1.40A 6b1eB-3tbkA:
undetectable		 6b1eB-3tbkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3tbk RIG-I HELICASE
DOMAIN
(Mus
musculus) 		5 / 9 MET A 480
SER A 477
ILE A 555
ALA A 564
LEU A 568
 None
 1.44A 6hqbB-3tbkA:
undetectable		 6hqbB-3tbkA:
8.47