SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		5 / 12 ILE A  25
LEU A 171
VAL A 162
LEU A 179
ILE A  24
 None
 0.97A 1df7A-3tc2A:
undetectable		 1df7A-3tc2A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		5 / 12 SER A  94
GLY A  39
ARG A 170
VAL A  52
GLU A 118
 None
 1.50A 3jb2A-3tc2A:
undetectable		 3jb2A-3tc2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		5 / 12 LEU A 171
GLY A  34
VAL A  59
PRO A  61
GLY A  30
 None
 1.03A 3ku1H-3tc2A:
undetectable		 3ku1H-3tc2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		4 / 5 ASP A  10
GLU A  15
TYR A  22
GLN A 185
 None
 1.35A 3w9tD-3tc2A:
5.4		 3w9tD-3tc2A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		4 / 5 ASP A  10
GLU A  15
TYR A  22
GLN A 185
 None
 1.34A 3w9tE-3tc2A:
4.6		 3w9tE-3tc2A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		4 / 5 ASP A  10
GLU A  15
TYR A  22
GLN A 185
 None
 1.36A 3w9tG-3tc2A:
4.6		 3w9tG-3tc2A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		3 / 3 GLU A  83
ASP A  82
ASP A   4
 None
 0.74A 4gc9A-3tc2A:
undetectable		 4gc9A-3tc2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		3 / 3 LYS A 104
TRP A 103
SER A 129
 None
 1.35A 5nwwA-3tc2A:
undetectable		 5nwwA-3tc2A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		4 / 8 LEU A 171
VAL A  52
VAL A  36
ILE A  87
 None
 0.72A 5y9mA-3tc2A:
undetectable		 5y9mA-3tc2A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5
(Solanum
tuberosum) 		3 / 3 ASP A  82
SER A  73
SER A  71
 None
 0.76A 6mxtA-3tc2A:
undetectable		 6mxtA-3tc2A:
18.63