SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 11 PHE A 160
ILE A 173
ASN A 175
GLY A 143
PHE A 156
 None
 1.33A 1ju6A-3tc3A:
undetectable		 1ju6A-3tc3A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 12 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 1.11A 1lbcA-3tc3A:
undetectable
1lbcC-3tc3A:
undetectable		 1lbcA-3tc3A:
24.54
1lbcC-3tc3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 9 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 1.07A 1lbcB-3tc3A:
undetectable		 1lbcB-3tc3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		3 / 3 GLU A 174
HIS A 202
HIS A 141
 MN  A 290 (-2.7A)
MN  A 290 (-4.4A)
None
 0.56A 1oe2A-3tc3A:
undetectable		 1oe2A-3tc3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 12 ASP A  88
GLY A  87
GLY A 133
ILE A  97
LEU A  41
 None
 0.85A 2nxeA-3tc3A:
undetectable		 2nxeA-3tc3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		4 / 6 HIS A  68
PHE A  71
LEU A  22
LEU A  25
 None
 1.17A 3bgdA-3tc3A:
undetectable		 3bgdA-3tc3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 11 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 1.04A 3h6tA-3tc3A:
undetectable
3h6tC-3tc3A:
undetectable		 3h6tA-3tc3A:
24.54
3h6tC-3tc3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 9 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 0.96A 3h6tB-3tc3A:
undetectable		 3h6tB-3tc3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 11 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 1.04A 3h6tA-3tc3A:
undetectable
3h6tC-3tc3A:
undetectable		 3h6tA-3tc3A:
24.54
3h6tC-3tc3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 9 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 1.05A 3tkdA-3tc3A:
undetectable		 3tkdA-3tc3A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A   2
HIS A   0
ARG A 226
 None
 0.99A 5iaoC-3tc3A:
undetectable		 5iaoC-3tc3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A   2
HIS A   0
ARG A 226
 None
 0.97A 5iaoF-3tc3A:
undetectable		 5iaoF-3tc3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		4 / 8 LEU A  45
ILE A  63
THR A  62
MET A 132
 None
 1.05A 5ljbA-3tc3A:
undetectable		 5ljbA-3tc3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		4 / 7 LEU A  45
ILE A  63
THR A  62
MET A 132
 None
 1.08A 5ljcA-3tc3A:
undetectable		 5ljcA-3tc3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 12 PHE A 160
ILE A 173
ASN A 175
GLY A 143
PHE A 156
 None
 1.26A 6r2eA-3tc3A:
undetectable		 6r2eA-3tc3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3tc3 UV DAMAGE
ENDONUCLEASE
(Sulfolobus
acidocaldarius) 		5 / 11 PHE A 160
ILE A 173
ASN A 175
GLY A 143
PHE A 156
 None
 1.20A 6r2eG-3tc3A:
undetectable		 6r2eG-3tc3A:
25.00