SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 11 GLY A 153
ALA A 154
VAL A 322
ILE A 285
ILE A 158
 None
 0.93A 1n49B-3tc8A:
undetectable		 1n49B-3tc8A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 11 GLY A 153
ALA A 154
VAL A 322
ILE A 285
ILE A 158
 None
 0.93A 1n49C-3tc8A:
undetectable		 1n49C-3tc8A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 7 VAL A 322
LEU A 323
ALA A 154
LEU A 219
 None
 0.63A 1pthA-3tc8A:
undetectable		 1pthA-3tc8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 7 VAL A 322
LEU A 323
ALA A 154
LEU A 219
 None
 0.63A 1pthB-3tc8A:
undetectable		 1pthB-3tc8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 ALA A 250
GLY A 254
GLY A 256
ALA A 317
THR A 314
 None
 1.17A 2c49A-3tc8A:
undetectable		 2c49A-3tc8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 HIS A 301
GLY A 182
GLU A 179
HIS A 122
ASP A 147
 ZN  A 350 ( 3.2A)
None
EDO  A 401 (-3.8A)
None
ZN  A 350 ( 2.3A)
 1.34A 2pgfA-3tc8A:
undetectable		 2pgfA-3tc8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 8 PHE A 296
ILE A 286
GLY A 265
GLY A 264
 EDO  A 401 ( 4.4A)
None
None
None
 0.88A 2qx4A-3tc8A:
2.2
2qx4B-3tc8A:
undetectable		 2qx4A-3tc8A:
22.33
2qx4B-3tc8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 8 LEU A 119
ILE A 171
TYR A 327
GLY A 163
 None
 0.96A 3b9lA-3tc8A:
undetectable		 3b9lA-3tc8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 GLY A 144
ALA A 145
GLY A 224
GLY A 223
VAL A 222
 None
 0.92A 3cyxB-3tc8A:
undetectable		 3cyxB-3tc8A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 ASP A 147
ASP A 146
GLY A 223
GLY A 153
ASP A 124
 ZN  A 350 ( 2.3A)
None
None
None
None
 1.12A 3prsA-3tc8A:
undetectable		 3prsA-3tc8A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 11 LEU A 323
VAL A 322
SER A  46
VAL A 152
PHE A  81
 None
 1.35A 3tbgA-3tc8A:
undetectable		 3tbgA-3tc8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 GLU A 179
HIS A 122
ASP A 270
ASP A 147
ASP A 269
 EDO  A 401 (-3.8A)
None
None
ZN  A 350 ( 2.3A)
EDO  A 401 ( 3.8A)
 1.49A 3ximC-3tc8A:
undetectable		 3ximC-3tc8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		3 / 3 PHE A 186
TYR A 181
TYR A  95
 None
 1.02A 4ffwA-3tc8A:
5.2		 4ffwA-3tc8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 7 GLY A 151
VAL A 152
PHE A  42
ILE A 158
 None
 0.91A 4fglC-3tc8A:
3.1		 4fglC-3tc8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		3 / 3 LYS A 231
LEU A 236
ALA A 263
 None
 0.75A 4iizA-3tc8A:
undetectable		 4iizA-3tc8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 6 ASP A 147
ASP A 180
ALA A 178
ASP A 220
 ZN  A 350 ( 2.3A)
ZN  A 350 (-1.9A)
None
EDO  A 401 (-4.0A)
 1.20A 4mdbA-3tc8A:
undetectable		 4mdbA-3tc8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 5 PRO A  59
GLY A 144
ASP A  72
ASP A 124
 None
 1.09A 4n48B-3tc8A:
undetectable		 4n48B-3tc8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 6 GLU A 313
GLY A 148
ASP A 147
GLY A 151
 None
None
ZN  A 350 ( 2.3A)
None
 0.81A 5cdnA-3tc8A:
undetectable
5cdnB-3tc8A:
2.6		 5cdnA-3tc8A:
20.83
5cdnB-3tc8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 6 GLU A 313
GLY A 148
ASP A 147
GLY A 151
 None
None
ZN  A 350 ( 2.3A)
None
 0.81A 5cdnR-3tc8A:
undetectable
5cdnS-3tc8A:
2.6		 5cdnR-3tc8A:
20.83
5cdnS-3tc8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		4 / 6 GLU A 313
GLY A 148
ASP A 147
GLY A 151
 None
None
ZN  A 350 ( 2.3A)
None
 0.82A 5cdnT-3tc8A:
undetectable
5cdnU-3tc8A:
2.6		 5cdnT-3tc8A:
20.83
5cdnU-3tc8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 ASP A 284
SER A 235
GLN A 233
ALA A 262
ALA A 263
 None
 1.38A 5cxvA-3tc8A:
undetectable		 5cxvA-3tc8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 LEU A 219
GLY A 144
ASP A 143
LEU A 155
ALA A 121
 None
 0.81A 5h5fA-3tc8A:
undetectable		 5h5fA-3tc8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 9 SER A  46
ASP A  41
TYR A 327
LEU A 323
PHE A  42
 None
 1.31A 5l1fB-3tc8A:
1.2		 5l1fB-3tc8A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 GLY A 223
GLY A 153
GLY A 151
ILE A 158
ALA A  47
 None
 0.97A 5x7fA-3tc8A:
undetectable		 5x7fA-3tc8A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 GLU A 179
HIS A 122
ASP A 270
ASP A 147
ASP A 269
 EDO  A 401 (-3.8A)
None
None
ZN  A 350 ( 2.3A)
EDO  A 401 ( 3.8A)
 1.49A 5ximA-3tc8A:
undetectable		 5ximA-3tc8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 GLU A 179
HIS A 122
ASP A 270
ASP A 147
ASP A 269
 EDO  A 401 (-3.8A)
None
None
ZN  A 350 ( 2.3A)
EDO  A 401 ( 3.8A)
 1.49A 5ximB-3tc8A:
undetectable		 5ximB-3tc8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 GLU A 179
HIS A 122
ASP A 270
ASP A 147
ASP A 269
 EDO  A 401 (-3.8A)
None
None
ZN  A 350 ( 2.3A)
EDO  A 401 ( 3.8A)
 1.48A 5ximC-3tc8A:
undetectable		 5ximC-3tc8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 GLU A 179
HIS A 122
ASP A 270
ASP A 147
ASP A 269
 EDO  A 401 (-3.8A)
None
None
ZN  A 350 ( 2.3A)
EDO  A 401 ( 3.8A)
 1.48A 5ximD-3tc8A:
undetectable		 5ximD-3tc8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 VAL A 222
LEU A 218
LEU A 155
ILE A 158
ALA A 154
 None
 1.26A 5xprA-3tc8A:
undetectable		 5xprA-3tc8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 9 PRO A 167
SER A 108
GLY A 170
LEU A 119
LEU A  78
 None
 1.38A 6dm0A-3tc8A:
1.9
6dm0D-3tc8A:
1.8		 6dm0A-3tc8A:
13.82
6dm0D-3tc8A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3tc8 LEUCINE
AMINOPEPTIDASE
(Parabacteroides
distasonis) 		5 / 12 LEU A 156
ASP A 146
GLY A 148
ILE A 286
LEU A 218
 None
 1.15A 6dwnC-3tc8A:
undetectable		 6dwnC-3tc8A:
14.79