SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 MET A 323
ALA A 403
ILE A 505
LEU A 396
LEU A 389
 None
 1.23A 1eiiA-3tchA:
undetectable		 1eiiA-3tchA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 391
TYR A 299
MET A 323
VAL A 508
 None
 1.02A 1fduB-3tchA:
undetectable		 1fduB-3tchA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 LYS A 163
THR A 173
THR A  99
VAL A  97
 None
 0.82A 1ictD-3tchA:
undetectable		 1ictD-3tchA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 TYR A 446
TYR A 141
LEU A 453
THR A 489
TYR A 492
 None
 1.07A 1mxfD-3tchA:
undetectable		 1mxfD-3tchA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 350
ASN A 447
LEU A 353
TYR A 347
TYR A 510
 None
 1.34A 1pj7A-3tchA:
undetectable		 1pj7A-3tchA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 ALA A 471
PHE A 472
ALA A 495
LEU A 453
 None
 0.75A 2bxmA-3tchA:
2.1		 2bxmA-3tchA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 439
SER A 394
TYR A 299
 None
 0.92A 2q2hA-3tchA:
undetectable
2q2hB-3tchA:
undetectable		 2q2hA-3tchA:
12.26
2q2hB-3tchA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 TYR A 180
ILE A 475
ASN A 454
LEU A 457
 None
 1.27A 2wekB-3tchA:
undetectable		 2wekB-3tchA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 301
GLY A 342
ALA A 340
ILE A 328
 None
 0.82A 3jusA-3tchA:
undetectable		 3jusA-3tchA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 301
GLY A 342
ALA A 340
ILE A 328
 None
 0.82A 3jusA-3tchA:
undetectable		 3jusA-3tchA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 439
GLU A 302
TYR A 343
 None
 0.88A 3k37B-3tchA:
undetectable		 3k37B-3tchA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 HIS A 168
SER A  89
GLU A  88
 None
 0.83A 3s8pA-3tchA:
undetectable		 3s8pA-3tchA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 ASP A 349
THR A 348
GLU A 448
LYS A 183
 None
 1.34A 4a3pA-3tchA:
undetectable		 4a3pA-3tchA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 LYS A 163
THR A 173
THR A  99
VAL A  97
 None
 0.92A 4ik7A-3tchA:
undetectable		 4ik7A-3tchA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 445
TRP A 423
SER A 137
 None
 1.08A 4lrhA-3tchA:
undetectable		 4lrhA-3tchA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 THR A 190
LEU A 185
PRO A  82
LEU A  74
 None
 0.95A 5g48A-3tchA:
undetectable		 5g48A-3tchA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 400
ALA A 404
LEU A 407
LEU A 389
 None
 0.81A 5vkqA-3tchA:
2.2
5vkqD-3tchA:
2.2		 5vkqA-3tchA:
14.37
5vkqD-3tchA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 389
LEU A 400
ALA A 404
LEU A 407
 None
 0.80A 5vkqA-3tchA:
2.2
5vkqB-3tchA:
2.2		 5vkqA-3tchA:
14.37
5vkqB-3tchA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 389
LEU A 400
ALA A 404
LEU A 407
 None
 0.79A 5vkqB-3tchA:
2.2
5vkqC-3tchA:
2.1		 5vkqB-3tchA:
14.37
5vkqC-3tchA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 389
LEU A 400
ALA A 404
LEU A 407
 None
 0.83A 5vkqC-3tchA:
2.1
5vkqD-3tchA:
2.2		 5vkqC-3tchA:
14.37
5vkqD-3tchA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 499
LEU A 353
THR A 450
PRO A 529
 None
 1.04A 6ew0F-3tchA:
undetectable		 6ew0F-3tchA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 499
LEU A 353
THR A 450
PRO A 529
 None
 1.04A 6ew0G-3tchA:
undetectable		 6ew0G-3tchA:
9.90