SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G1U_B_ADNB438_2 (ADENOSYLHOMOCYSTEINA SE)	3tcl	CH04 HEAVY CHAIN FAB (Homo sapiens)	3 / 3	THR H 110 GLU H 148 HIS H 200	None	0.80A	3g1uB-3tclH: undetectable	3g1uB-3tclH: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_A_PNNA302_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	3tcl	CH04 HEAVY CHAIN FAB (Homo sapiens)	4 / 6	LEU H 189 GLY H 190 ALA H 125 PRO H 126	None	0.49A	3huoA-3tclH: undetectable	3huoA-3tclH: 21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_0 (16S RRNA METHYLASE)	3tcl	CH04 HEAVY CHAIN FAB (Homo sapiens)	5 / 12	GLY H 33 GLY H 100 ASN H 53 ALA H 93 TRP H 100	None	1.06A	3p2kA-3tclH: undetectable	3p2kA-3tclH: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_B_SAMB6735_0 (16S RRNA METHYLASE)	3tcl	CH04 HEAVY CHAIN FAB (Homo sapiens)	5 / 12	GLY H 33 GLY H 100 ASN H 53 ALA H 93 TRP H 100	None	1.06A	3p2kB-3tclH: undetectable	3p2kB-3tclH: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE1_A_X2NA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3tcl	CH04 HEAVY CHAIN FAB (Homo sapiens)	5 / 12	TYR H 59 GLY H 60 LEU H 82 GLY H 10 LEU H 20	None	1.27A	4ze1A-3tclH: undetectable	4ze1A-3tclH: 19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQG_A_ERMA1201_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562)	3tcl	CH04 HEAVY CHAIN FAB (Homo sapiens)	5 / 12	VAL H 211 GLY H 157 ALA H 158 SER H 180 VAL H 184	None	1.01A	6bqgA-3tclH: undetectable	6bqgA-3tclH: 13.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3G1U_B_ADNB438_2","ADENOSYLHOMOCYSTEINASE","3tcl","CH04 HEAVY CHAIN FAB","Homo sapiens",3,"THR H 110;GLU H 148;HIS H 200","None","0.80A","3g1uB-3tclH:undetectable","3g1uB-3tclH:21.62"],["3HUO_A_PNNA302_0","CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE","3tcl","CH04 HEAVY CHAIN FAB","Homo sapiens",4,"LEU H 189;GLY H 190;ALA H 125;PRO H 126","None","0.49A","3huoA-3tclH:undetectable","3huoA-3tclH:21.94"],["3P2K_A_SAMA6735_0","16S RRNA METHYLASE","3tcl","CH04 HEAVY CHAIN FAB","Homo sapiens",5,"GLY H  33;GLY H 100;ASN H  53;ALA H  93;TRP H 100","None","1.06A","3p2kA-3tclH:undetectable","3p2kA-3tclH:20.62"],["3P2K_B_SAMB6735_0","16S RRNA METHYLASE","3tcl","CH04 HEAVY CHAIN FAB","Homo sapiens",5,"GLY H  33;GLY H 100;ASN H  53;ALA H  93;TRP H 100","None","1.06A","3p2kB-3tclH:undetectable","3p2kB-3tclH:20.62"],["4ZE1_A_X2NA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","3tcl","CH04 HEAVY CHAIN FAB","Homo sapiens",5,"TYR H  59;GLY H  60;LEU H  82;GLY H  10;LEU H  20","None","1.27A","4ze1A-3tclH:undetectable","4ze1A-3tclH:19.59"],["6BQG_A_ERMA1201_1","5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562","3tcl","CH04 HEAVY CHAIN FAB","Homo sapiens",5,"VAL H 211;GLY H 157;ALA H 158;SER H 180;VAL H 184","None","1.01A","6bqgA-3tclH:undetectable","6bqgA-3tclH:13.50"]]