SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 5 GLY A 300
GLN A 262
VAL A 346
SER A 296
 None
None
None
DCS  A 501 (-2.6A)
 1.47A 1p6kB-3tcmA:
undetectable		 1p6kB-3tcmA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 5 GLY A 300
GLN A 262
VAL A 346
SER A 296
 None
None
None
DCS  A 501 (-2.6A)
 1.44A 1rs6B-3tcmA:
undetectable		 1rs6B-3tcmA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		6 / 12 ALA A 422
GLY A 443
GLY A 441
LEU A 188
ILE A 171
TYR A 192
 None
 1.44A 1x1aA-3tcmA:
3.8		 1x1aA-3tcmA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 5 GLY A 300
GLN A 262
VAL A 346
SER A 296
 None
None
None
DCS  A 501 (-2.6A)
 1.46A 1zzuB-3tcmA:
undetectable		 1zzuB-3tcmA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 5 ASP A 146
SER A 335
LEU A 342
GLY A 309
 None
 1.17A 2j2pA-3tcmA:
undetectable
2j2pB-3tcmA:
undetectable		 2j2pA-3tcmA:
17.97
2j2pB-3tcmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		5 / 10 ALA A 137
ASN A 138
ALA A 139
ALA A 126
SER A 127
 None
 1.02A 2r2vC-3tcmA:
undetectable
2r2vF-3tcmA:
undetectable
2r2vG-3tcmA:
undetectable		 2r2vC-3tcmA:
6.21
2r2vF-3tcmA:
6.21
2r2vG-3tcmA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 7 ARG A 214
LEU A 210
GLN A 209
PHE A 247
 None
 1.00A 3ag2P-3tcmA:
undetectable
3ag2W-3tcmA:
undetectable		 3ag2P-3tcmA:
18.40
3ag2W-3tcmA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 6 TYR A 424
ALA A 425
LEU A 428
THR A 454
 None
 0.84A 3b6hB-3tcmA:
undetectable		 3b6hB-3tcmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		6 / 12 VAL A  70
THR A 109
ILE A 104
PRO A 105
LEU A 121
ILE A 341
 None
 1.38A 3clbC-3tcmA:
2.3		 3clbC-3tcmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 7 TYR A 301
GLU A 304
LEU A 368
ASN A 264
 None
 1.33A 3k8mB-3tcmA:
undetectable		 3k8mB-3tcmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 8 ILE A  48
TYR A  50
GLN A  33
LEU A  32
 None
 0.80A 3ozwA-3tcmA:
2.3		 3ozwA-3tcmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		5 / 12 GLY A 147
ARG A 308
GLY A 339
SER A 298
GLU A 259
 DCS  A 501 (-3.5A)
DCS  A 501 (-3.5A)
None
DCS  A 501 (-2.9A)
None
 1.33A 3tkaA-3tcmA:
6.1		 3tkaA-3tcmA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 7 SER A 113
GLY A 110
THR A 109
ILE A 337
 None
 0.83A 4acaC-3tcmA:
4.7		 4acaC-3tcmA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 6 ILE A 388
ILE A 466
PHE A 451
LEU A 428
 None
 0.74A 4m51A-3tcmA:
undetectable		 4m51A-3tcmA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		5 / 12 LEU A 255
VAL A 279
ILE A 278
LEU A 201
LEU A 236
 None
 0.96A 4yvpB-3tcmA:
undetectable		 4yvpB-3tcmA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 8 PHE A 472
GLU A 430
HIS A  28
THR A 454
 None
 1.46A 5hqaA-3tcmA:
2.0		 5hqaA-3tcmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		5 / 10 ALA A 375
ILE A 455
TYR A 398
GLY A 300
GLY A 395
 None
None
DCS  A 501 (-4.4A)
None
None
 1.13A 5i6xA-3tcmA:
undetectable		 5i6xA-3tcmA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 5 ALA A 126
ALA A 139
ILE A 142
LEU A 144
 None
 0.80A 5jncD-3tcmA:
undetectable		 5jncD-3tcmA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		5 / 12 SER A 131
GLY A 128
ALA A 126
MET A 347
SER A 274
 None
 1.35A 5lf3b-3tcmA:
undetectable		 5lf3b-3tcmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		5 / 12 SER A 131
GLY A 128
ALA A 126
MET A 347
SER A 274
 None
 1.35A 5lf3N-3tcmA:
undetectable		 5lf3N-3tcmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		4 / 5 GLY A 300
GLN A 262
VAL A 346
SER A 296
 None
None
None
DCS  A 501 (-2.6A)
 1.48A 5vunA-3tcmA:
undetectable		 5vunA-3tcmA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3tcm ALANINE
AMINOTRANSFERASE 2
(Hordeum
vulgare) 		5 / 12 PHE A 442
LEU A 193
SER A 178
GLN A 173
ASP A 421
 None
 1.41A 6bxnA-3tcmA:
2.0		 6bxnA-3tcmA:
22.01