SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 3tco THIOREDOXIN (TRXA-1)
(Sulfolobus
solfataricus) 		5 / 9 TYR A  95
LEU A  83
ASP A  39
ILE A  42
VAL A  41
 None
 1.25A 2l8mA-3tcoA:
undetectable		 2l8mA-3tcoA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3tco THIOREDOXIN (TRXA-1)
(Sulfolobus
solfataricus) 		5 / 11 TYR A 131
LEU A 132
LYS A 130
LEU A  47
THR A 123
 None
None
EDO  A 504 (-2.7A)
None
None
 1.44A 2x7hA-3tcoA:
undetectable
2x7hB-3tcoA:
undetectable		 2x7hA-3tcoA:
15.88
2x7hB-3tcoA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3tco THIOREDOXIN (TRXA-1)
(Sulfolobus
solfataricus) 		5 / 12 LEU A  33
LEU A 104
ILE A  42
ILE A  91
TYR A  95
 None
 1.25A 4a79A-3tcoA:
undetectable		 4a79A-3tcoA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3tco THIOREDOXIN (TRXA-1)
(Sulfolobus
solfataricus) 		5 / 11 LEU A  33
LEU A 104
ILE A  42
ILE A  91
TYR A  95
 None
 1.25A 4a7aA-3tcoA:
undetectable		 4a7aA-3tcoA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3tco THIOREDOXIN (TRXA-1)
(Sulfolobus
solfataricus) 		4 / 5 TYR A  74
LYS A  73
LEU A 124
GLU A 121
 None
 1.48A 6cbdA-3tcoA:
undetectable		 6cbdA-3tcoA:
8.94