SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tcq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3tcq MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.06A 1tw4A-3tcqA:
undetectable		 1tw4A-3tcqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3tcq MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		3 / 3 ALA A  70
THR A 190
PHE A  73
 None
 0.60A 2c6nB-3tcqA:
undetectable		 2c6nB-3tcqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3tcq MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.13A 2jn3A-3tcqA:
undetectable		 2jn3A-3tcqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3tcq MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 LEU A  75
THR A 123
ILE A 122
TYR A 120
ILE A 115
 None
 1.18A 3vw1D-3tcqA:
undetectable		 3vw1D-3tcqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3tcq MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		4 / 7 LEU A 147
TYR A 120
ARG A  52
LEU A 181
 None
 0.96A 5zcqA-3tcqA:
undetectable
5zcqJ-3tcqA:
undetectable		 5zcqA-3tcqA:
20.38
5zcqJ-3tcqA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3tcq MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		4 / 6 ARG A 137
ALA A 118
LEU A 117
ALA A 113
 None
 1.19A 6fosB-3tcqA:
undetectable		 6fosB-3tcqA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3tcq MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 PHE A 209
LEU A 207
ILE A 284
GLY A 260
ILE A 258
 None
 0.99A 6iftA-3tcqA:
undetectable		 6iftA-3tcqA:
21.87