SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 5 GLU A   7
THR A   8
HIS A  44
LEU A  52
 None
 1.15A 1d4fC-3tcsA:
undetectable		 1d4fC-3tcsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 6 ALA A 218
LYS A 221
ASP A 225
ALA A 226
 None
 0.40A 1iwhA-3tcsA:
undetectable		 1iwhA-3tcsA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ALA A  81
GLY A  84
GLY A 264
THR A   8
VAL A  17
 None
 1.09A 2okcA-3tcsA:
undetectable		 2okcA-3tcsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 8 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.82A 2po5A-3tcsA:
undetectable		 2po5A-3tcsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 8 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.87A 2po5B-3tcsA:
undetectable		 2po5B-3tcsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 GLN A  30
THR A 330
TRP A 289
 None
PG4  A 372 ( 4.0A)
None
 1.04A 2rctA-3tcsA:
undetectable		 2rctA-3tcsA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		5 / 10 VAL A 272
LEU A  63
LEU A 262
ARG A 267
GLY A 264
 None
 1.02A 2xf3A-3tcsA:
undetectable		 2xf3A-3tcsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 8 VAL A 272
LEU A  63
ARG A 267
GLY A 264
 None
 0.93A 2xfsA-3tcsA:
undetectable		 2xfsA-3tcsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 8 VAL A 272
LEU A  63
ARG A 267
GLY A 264
 None
 0.95A 2xh9A-3tcsA:
undetectable		 2xh9A-3tcsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		5 / 10 ILE A 334
ALA A 339
THR A 232
ILE A 303
ILE A 265
 PG4  A 372 ( 4.9A)
None
None
None
None
 1.16A 3prsA-3tcsA:
undetectable		 3prsA-3tcsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLN A 256
GLN A 236
ASP A 183
SER A 118
MET A 119
 None
None
MG  A 368 ( 2.7A)
None
DAL  A 370 (-3.5A)
 1.27A 3t7sA-3tcsA:
undetectable		 3t7sA-3tcsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_C_ACTC1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 4 ARG A  79
GLN A  46
GLU A  70
THR A  67
 None
 1.37A 4eahC-3tcsA:
0.0
4eahH-3tcsA:
0.5		 4eahC-3tcsA:
22.39
4eahH-3tcsA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 6 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 368 ( 2.7A)
None
None
None
 1.07A 4oltA-3tcsA:
undetectable		 4oltA-3tcsA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 6 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 368 ( 2.7A)
None
None
None
 1.08A 4oltB-3tcsA:
undetectable		 4oltB-3tcsA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 5 HIS A 207
VAL A 231
GLU A 209
LYS A 145
 None
None
MG  A 368 ( 2.8A)
DAL  A 370 (-2.9A)
 1.34A 4p6vB-3tcsA:
undetectable
4p6vE-3tcsA:
undetectable		 4p6vB-3tcsA:
23.28
4p6vE-3tcsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 7 GLU A 209
PHE A 205
LYS A 145
HIS A 207
 MG  A 368 ( 2.8A)
None
DAL  A 370 (-2.9A)
None
 1.28A 4uciB-3tcsA:
undetectable		 4uciB-3tcsA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		5 / 9 LEU A  63
THR A  21
VAL A  19
VAL A  85
LEU A  92
 None
 1.41A 4wnvA-3tcsA:
undetectable		 4wnvA-3tcsA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		6 / 10 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.43A 5lf3H-3tcsA:
undetectable
5lf3I-3tcsA:
undetectable		 5lf3H-3tcsA:
19.59
5lf3I-3tcsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		6 / 10 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.43A 5lf3V-3tcsA:
undetectable
5lf3W-3tcsA:
undetectable		 5lf3V-3tcsA:
19.59
5lf3W-3tcsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		6 / 11 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.44A 5lf7H-3tcsA:
undetectable
5lf7I-3tcsA:
undetectable		 5lf7H-3tcsA:
19.59
5lf7I-3tcsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		6 / 11 THR A   8
GLU A   7
ALA A  83
GLY A  84
ALA A  88
THR A  87
 None
 1.45A 5lf7V-3tcsA:
undetectable
5lf7W-3tcsA:
undetectable		 5lf7V-3tcsA:
19.59
5lf7W-3tcsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 7 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.90A 5u4sA-3tcsA:
undetectable		 5u4sA-3tcsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		4 / 8 ILE A 259
LEU A 299
LEU A 300
PRO A 257
 None
 0.91A 5u4sB-3tcsA:
undetectable		 5u4sB-3tcsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3tcs RACEMASE, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ASP A 179
ARG A 113
LEU A 294
ALA A 102
ILE A 303
 None
 1.08A 5vc0A-3tcsA:
undetectable		 5vc0A-3tcsA:
22.16