SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 PRO A 157
LEU A 166
TYR A 222
LEU A 139
MET A 201
 None
 1.43A 1e7wA-3tdgA:
undetectable		 1e7wA-3tdgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 TYR A 222
ILE A 153
PRO A 258
GLU A 165
 None
 1.44A 1oniA-3tdgA:
undetectable
1oniC-3tdgA:
undetectable		 1oniA-3tdgA:
22.22
1oniC-3tdgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 5 VAL A 183
VAL A 182
GLN A 163
PHE A 259
 None
 1.33A 3bjwB-3tdgA:
undetectable		 3bjwB-3tdgA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 ASP A  68
VAL A  47
GLY A  88
ILE A  87
ILE A  39
 None
 1.02A 3d1zA-3tdgA:
undetectable		 3d1zA-3tdgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		6 / 9 ASP A  68
VAL A  47
GLY A  88
ILE A  87
VAL A  38
ILE A  39
 None
 1.40A 3ekvB-3tdgA:
undetectable		 3ekvB-3tdgA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 ILE A 215
TYR A 222
MET A 201
ILE A 137
 None
None
None
FMT  A 360 (-4.6A)
 1.16A 3eteA-3tdgA:
undetectable
3eteE-3tdgA:
undetectable		 3eteA-3tdgA:
20.44
3eteE-3tdgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 5 ILE A 215
TYR A 222
MET A 201
ILE A 137
 None
None
None
FMT  A 360 (-4.6A)
 1.15A 3eteB-3tdgA:
undetectable
3eteC-3tdgA:
undetectable		 3eteB-3tdgA:
20.44
3eteC-3tdgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 7 MET A 201
ILE A 137
ILE A 215
TYR A 222
 None
FMT  A 360 (-4.6A)
None
None
 1.15A 3eteD-3tdgA:
undetectable
3eteF-3tdgA:
undetectable		 3eteD-3tdgA:
20.44
3eteF-3tdgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A 188
ALA A 194
ALA A 195
GLN A 198
LEU A 237
 None
 0.63A 3fc6C-3tdgA:
undetectable		 3fc6C-3tdgA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		6 / 10 ASP A  68
VAL A  47
GLY A  88
ILE A  87
VAL A  38
ILE A  39
 None
 1.35A 3nu6A-3tdgA:
undetectable		 3nu6A-3tdgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		6 / 10 ASP A  68
VAL A  47
GLY A  88
ILE A  87
VAL A  38
ILE A  39
 None
 1.40A 3nujA-3tdgA:
undetectable		 3nujA-3tdgA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 THR A  71
GLN A 119
TYR A  73
ILE A  75
 None
None
None
P6G  A 401 ( 4.1A)
 1.14A 3peoG-3tdgA:
undetectable		 3peoG-3tdgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 GLY A 184
GLY A 187
SER A 155
GLU A 242
ALA A 194
 None
 1.18A 3sxjB-3tdgA:
undetectable		 3sxjB-3tdgA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		6 / 12 ASP A  68
VAL A  47
GLY A  88
ILE A  87
VAL A  38
ILE A  39
 None
 1.35A 4dqfA-3tdgA:
undetectable		 4dqfA-3tdgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 5 LEU A  77
GLY A  88
ILE A  39
LYS A  45
 None
 1.11A 4ma8C-3tdgA:
undetectable		 4ma8C-3tdgA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		6 / 10 ASP A  68
VAL A  47
GLY A  88
ILE A  87
VAL A  38
ILE A  39
 None
 1.41A 4q1wB-3tdgA:
undetectable		 4q1wB-3tdgA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 7 ASN A 146
LYS A 147
LYS A 149
TYR A 152
PHE A 259
 None
 1.47A 4yv5B-3tdgA:
undetectable		 4yv5B-3tdgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 4 VAL A 101
ALA A 105
ASN A 108
GLN A 109
 None
None
P6G  A 401 ( 4.0A)
None
 1.35A 4zgfA-3tdgA:
undetectable		 4zgfA-3tdgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 10 ILE A  86
ILE A  39
VAL A  79
ASP A  33
ILE A  49
 None
 1.26A 5lg3F-3tdgA:
undetectable		 5lg3F-3tdgA:
20.87