SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tdm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3tdm COMPUTATIONALLY
DESIGNED TWO-FOLD
SYMMETRIC TIM-BARREL
PROTEIN, FLR (HALF
MOLECULE)
(synthetic
construct) 		3 / 3 GLY A  81
TYR A  61
SER A  80
 PO4  A 122 ( 3.9A)
None
PO4  A 122 ( 4.3A)
 0.63A 2xatA-3tdmA:
undetectable		 2xatA-3tdmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3tdm COMPUTATIONALLY
DESIGNED TWO-FOLD
SYMMETRIC TIM-BARREL
PROTEIN, FLR (HALF
MOLECULE)
(synthetic
construct) 		3 / 3 MET A  86
VAL A 100
GLU A  91
 None
 0.89A 3c6gA-3tdmA:
undetectable		 3c6gA-3tdmA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 3tdm COMPUTATIONALLY
DESIGNED TWO-FOLD
SYMMETRIC TIM-BARREL
PROTEIN, FLR (HALF
MOLECULE)
(synthetic
construct) 		4 / 4 PHE A  89
LYS A  85
ILE A 102
THR A 119
 None
 1.31A 3ia4B-3tdmA:
undetectable		 3ia4B-3tdmA:
22.54