SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tdp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		4 / 7 THR A 104
SER A 105
TYR A 250
LEU A   6
 None
BOG  A 267 (-2.8A)
None
None
 1.03A 1ibgL-3tdpA:
undetectable		 1ibgL-3tdpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		3 / 3 ALA A 226
VAL A 231
TRP A 112
 None
 0.92A 1jo3A-3tdpA:
undetectable		 1jo3A-3tdpA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		3 / 3 ALA A 226
VAL A 231
TRP A 112
 None
 0.92A 1jo3B-3tdpA:
undetectable		 1jo3B-3tdpA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		4 / 7 ASN A 115
LEU A  82
THR A  80
VAL A  75
 None
 1.10A 2uz2A-3tdpA:
undetectable		 2uz2A-3tdpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		3 / 3 VAL A 171
ASN A  86
TRP A 108
 None
 1.12A 2y00B-3tdpA:
undetectable		 2y00B-3tdpA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		4 / 7 ILE A  42
GLY A  41
PHE A 194
ILE A 195
 None
 0.80A 2y7wC-3tdpA:
undetectable		 2y7wC-3tdpA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		5 / 12 GLY A  93
ASN A  96
GLY A  85
ASN A  11
LEU A   6
 None
 1.19A 3eeyJ-3tdpA:
undetectable		 3eeyJ-3tdpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		5 / 12 ILE A 218
GLY A  39
PHE A 194
ILE A 195
ILE A  45
 None
 0.99A 3pwwA-3tdpA:
undetectable		 3pwwA-3tdpA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		4 / 8 THR A 234
GLY A 241
GLY A 240
VAL A 239
 None
 0.72A 4qvvK-3tdpA:
undetectable
4qvvL-3tdpA:
undetectable		 4qvvK-3tdpA:
22.66
4qvvL-3tdpA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		4 / 8 THR A 234
GLY A 241
GLY A 240
VAL A 239
 None
 0.71A 4qvvY-3tdpA:
undetectable
4qvvZ-3tdpA:
undetectable		 4qvvY-3tdpA:
22.66
4qvvZ-3tdpA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tdp FORMATE/NITRITE
TRANSPORTER
(Clostridioides
difficile) 		5 / 12 GLY A 240
LEU A 191
ILE A  70
GLY A  39
LEU A  82
 None
 1.11A 4ze2A-3tdpA:
undetectable		 4ze2A-3tdpA:
19.40