SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 10 GLY A 101
PHE A 202
MET A 105
LEU A 108
LEU A 206
 None
 1.47A 1a8uA-3tdwA:
undetectable		 1a8uA-3tdwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 10 GLY A 101
PHE A 202
MET A 105
LEU A 108
LEU A 206
 None
 1.45A 1a8uB-3tdwA:
undetectable		 1a8uB-3tdwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 4 HIS A 201
ASP A 230
SER A 225
ASP A 196
 MG  A 501 ( 3.4A)
None
None
None
 1.49A 1n2xA-3tdwA:
undetectable		 1n2xA-3tdwA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 8 HIS A 194
ASP A 230
THR A 143
ASP A 196
 None
 1.21A 1rg9A-3tdwA:
undetectable		 1rg9A-3tdwA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 8 HIS A 194
ASP A 230
THR A 143
ASP A 196
 None
 1.18A 1rg9B-3tdwA:
undetectable		 1rg9B-3tdwA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 6 ASP A 237
TYR A 233
ASP A 196
GLU A 295
 None
 1.28A 1rjdB-3tdwA:
undetectable		 1rjdB-3tdwA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 6 ASP A 237
TYR A 233
ASP A 196
GLU A 295
 None
 1.29A 1rjdC-3tdwA:
undetectable		 1rjdC-3tdwA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		3 / 3 ARG A 115
ARG A 209
PRO A 212
 None
 1.11A 2wljA-3tdwA:
undetectable		 2wljA-3tdwA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 8 ASP A 196
HIS A 201
ASP A 221
GLU A 288
 None
MG  A 501 ( 3.4A)
MG  A 503 ( 4.7A)
None
 0.94A 3sg9B-3tdwA:
29.5		 3sg9B-3tdwA:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 10 PHE A  44
PHE A  89
PHE A  46
PHE A  16
ILE A  21
 None
 1.40A 3t3qA-3tdwA:
undetectable		 3t3qA-3tdwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		3 / 3 HIS A 201
HIS A 194
ILE A 216
 MG  A 501 ( 3.4A)
None
None
 0.81A 3u52A-3tdwA:
undetectable
3u52C-3tdwA:
undetectable		 3u52A-3tdwA:
21.28
3u52C-3tdwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		3 / 3 ARG A 260
ARG A 244
ASP A 254
 None
 0.89A 3wipG-3tdwA:
undetectable
3wipH-3tdwA:
undetectable		 3wipG-3tdwA:
23.43
3wipH-3tdwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 11 THR A 143
SER A 225
PHE A 265
VAL A 266
TYR A 233
 None
 1.44A 4claA-3tdwA:
undetectable		 4claA-3tdwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 12 PHE A 130
ALA A 135
VAL A 140
ALA A 129
ASP A 230
 None
 1.47A 4df3B-3tdwA:
undetectable		 4df3B-3tdwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		6 / 11 GLY A  28
ALA A  35
PRO A  75
HIS A 201
LEU A 203
ILE A 217
 GDP  A 500 (-3.4A)
GDP  A 500 (-3.6A)
None
MG  A 501 ( 3.4A)
None
GDP  A 500 ( 4.1A)
 0.52A 4dt8A-3tdwA:
29.6		 4dt8A-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 10 GLY A  28
ALA A  35
PRO A  75
LEU A 203
ILE A 217
 GDP  A 500 (-3.4A)
GDP  A 500 (-3.6A)
None
None
GDP  A 500 ( 4.1A)
 0.37A 4dt8B-3tdwA:
29.9		 4dt8B-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		6 / 10 ALA A  35
PRO A  75
LYS A  94
HIS A 201
LEU A 203
ILE A 217
 GDP  A 500 (-3.6A)
None
GDP  A 500 (-4.3A)
MG  A 501 ( 3.4A)
None
GDP  A 500 ( 4.1A)
 0.65A 4dtaA-3tdwA:
29.7		 4dtaA-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 8 PRO A  75
LYS A  94
LEU A 203
ILE A 217
 None
GDP  A 500 (-4.3A)
None
GDP  A 500 ( 4.1A)
 0.63A 4dtaB-3tdwA:
30.0		 4dtaB-3tdwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 12 SER A 198
TYR A 233
GLN A 270
ASP A 221
ASP A 218
 None
None
None
MG  A 503 ( 4.7A)
MG  A 502 (-1.9A)
 1.43A 4iilA-3tdwA:
undetectable		 4iilA-3tdwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 12 ILE A 217
ASP A 200
LEU A 120
LEU A 213
ILE A 216
 GDP  A 500 ( 4.1A)
MG  A 501 ( 4.9A)
None
None
None
 1.06A 4m2xE-3tdwA:
undetectable		 4m2xE-3tdwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 11 ASP A 196
SER A 198
ASP A 221
TYR A 233
TYR A 273
 None
None
MG  A 503 ( 4.7A)
None
None
 1.01A 5iqeA-3tdwA:
27.4		 5iqeA-3tdwA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		5 / 12 ASP A 196
SER A 198
ASP A 221
TYR A 233
TYR A 273
 None
None
MG  A 503 ( 4.7A)
None
None
 1.07A 5iqeC-3tdwA:
27.1		 5iqeC-3tdwA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3tdw GENTAMICIN
RESISTANCE PROTEIN
(Enterococcus
gallinarum) 		4 / 8 LEU A  27
VAL A  43
ILE A 217
ASP A 218
 GDP  A 500 (-4.4A)
None
GDP  A 500 ( 4.1A)
MG  A 502 (-1.9A)
 0.33A 5y9mX-3tdwA:
9.4		 5y9mX-3tdwA:
12.79