SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 7 PHE A 254
SER A 213
PHE A 285
ILE A 252
None
1.00A 1fxhA-3tefA:
undetectable
1fxhB-3tefA:
undetectable
1fxhA-3tefA:
20.81
1fxhB-3tefA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
3 / 3 ALA A 302
VAL A 268
TRP A 309
None
0.94A 1jo4A-3tefA:
undetectable
1jo4A-3tefA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
3 / 3 ALA A 302
VAL A 268
TRP A 309
None
0.94A 1jo4B-3tefA:
undetectable
1jo4B-3tefA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 7 LEU A 210
LEU A 265
TYR A 256
LEU A 218
None
1.09A 1kt3A-3tefA:
undetectable
1kt3A-3tefA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 11 LEU A 210
LEU A 265
VAL A 267
TYR A 256
LEU A 218
None
1.29A 1kt6A-3tefA:
undetectable
1kt6A-3tefA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
3 / 3 ALA A 302
VAL A 268
TRP A 309
None
0.96A 1nrmA-3tefA:
undetectable
1nrmA-3tefA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
3 / 3 ALA A 302
VAL A 268
TRP A 309
None
0.96A 1nrmB-3tefA:
undetectable
1nrmB-3tefA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 12 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.29A 1q23B-3tefA:
undetectable
1q23B-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 12 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.32A 1q23C-3tefA:
undetectable
1q23C-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 10 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.33A 1q23E-3tefA:
undetectable
1q23E-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 11 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.26A 1q23F-3tefA:
undetectable
1q23F-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 11 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.35A 1q23I-3tefA:
undetectable
1q23I-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 10 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.25A 1q23K-3tefA:
undetectable
1q23K-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
3 / 3 ARG A  70
SER A 141
TYR A 142
None
0.74A 1x70A-3tefA:
undetectable
1x70A-3tefA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
3 / 3 SER A 225
GLY A 222
SER A 229
None
0.64A 3loqA-3tefA:
2.9
3loqA-3tefA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 6 LEU A 304
VAL A 268
MET A 212
PHE A 227
None
1.11A 3soaA-3tefA:
undetectable
3soaA-3tefA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 10 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.32A 3u9fI-3tefA:
undetectable
3u9fI-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 12 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
None
1.30A 3u9fJ-3tefA:
undetectable
3u9fK-3tefA:
undetectable
3u9fJ-3tefA:
21.17
3u9fK-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 5 ASP A 233
GLU A 164
GLY A 161
TYR A 162
None
1.21A 3w9tB-3tefA:
undetectable
3w9tB-3tefA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 5 ASP A 233
GLU A 164
GLY A 161
TYR A 162
None
1.16A 3w9tD-3tefA:
undetectable
3w9tD-3tefA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 5 ASP A 233
GLU A 164
GLY A 161
TYR A 162
None
1.21A 3w9tG-3tefA:
undetectable
3w9tG-3tefA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 6 GLU A 157
GLN A 169
VAL A 133
THR A 151
None
1.30A 4lnxA-3tefA:
undetectable
4lnxA-3tefA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 12 VAL A  73
LEU A 116
GLY A  75
LEU A 102
THR A  98
None
1.30A 4o5fA-3tefA:
2.6
4o5fB-3tefA:
2.0
4o5fA-3tefA:
22.44
4o5fB-3tefA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 11 HIS A 248
SER A 247
THR A 220
THR A 219
SER A 228
None
1.37A 4qvyV-3tefA:
undetectable
4qvyb-3tefA:
undetectable
4qvyV-3tefA:
23.84
4qvyb-3tefA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 11 HIS A 248
SER A 247
THR A 220
THR A 219
SER A 228
None
1.38A 4qvyH-3tefA:
undetectable
4qvyN-3tefA:
undetectable
4qvyH-3tefA:
23.84
4qvyN-3tefA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 8 ALA A 155
SER A 314
SER A 165
ALA A 158
None
0.72A 4twdF-3tefA:
undetectable
4twdG-3tefA:
undetectable
4twdH-3tefA:
undetectable
4twdI-3tefA:
undetectable
4twdJ-3tefA:
undetectable
4twdF-3tefA:
21.75
4twdG-3tefA:
21.75
4twdH-3tefA:
21.75
4twdI-3tefA:
21.75
4twdJ-3tefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
4 / 8 ALA A 155
SER A 314
SER A 165
ALA A 158
None
0.75A 4twdF-3tefA:
undetectable
4twdG-3tefA:
undetectable
4twdH-3tefA:
undetectable
4twdI-3tefA:
undetectable
4twdJ-3tefA:
undetectable
4twdF-3tefA:
21.75
4twdG-3tefA:
21.75
4twdH-3tefA:
21.75
4twdI-3tefA:
21.75
4twdJ-3tefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 12 VAL A  73
LEU A 116
GLY A  75
LEU A 102
THR A  98
None
1.29A 5b8hA-3tefA:
3.9
5b8hB-3tefA:
2.3
5b8hA-3tefA:
20.24
5b8hB-3tefA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 11 HIS A 248
SER A 247
THR A 220
THR A 219
SER A 228
None
1.37A 5l5fV-3tefA:
undetectable
5l5fb-3tefA:
undetectable
5l5fV-3tefA:
23.84
5l5fb-3tefA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 11 HIS A 248
SER A 247
THR A 220
THR A 219
SER A 228
None
1.37A 5l5fH-3tefA:
undetectable
5l5fN-3tefA:
undetectable
5l5fH-3tefA:
23.84
5l5fN-3tefA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
5 / 12 LEU A 131
PHE A 177
ALA A 155
ILE A 313
GLY A 315
None
1.00A 5veuB-3tefA:
undetectable
5veuB-3tefA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio
cholerae)
3 / 3 VAL A 153
TYR A 142
GLU A 157
None
0.94A 5zmqD-3tefA:
undetectable
5zmqE-3tefA:
undetectable
5zmqD-3tefA:
20.66
5zmqE-3tefA:
12.18