SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3teh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 LEU A 110
PHE A 114
LEU A 322
LEU A 280
ALA A 241
 None
 1.26A 2bxeA-3tehA:
undetectable		 2bxeA-3tehA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
 None
 1.13A 2bxeA-3tehA:
undetectable		 2bxeA-3tehA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
 None
 1.09A 2bxeB-3tehA:
undetectable		 2bxeB-3tehA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
 None
 1.15A 2bxpA-3tehA:
undetectable		 2bxpA-3tehA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 GLN A 242
LYS A 250
VAL A 269
 None
 0.90A 2jfaB-3tehA:
undetectable		 2jfaB-3tehA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 SER A 180
THR A 179
GLY A 282
GLY A 316
VAL A 261
 DAH  A 351 (-2.9A)
None
DAH  A 351 (-4.0A)
DAH  A 351 (-2.9A)
DAH  A 351 (-4.6A)
 0.97A 3fzgA-3tehA:
undetectable		 3fzgA-3tehA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 TYR A 307
PHE A 291
VAL A 294
THR A 179
 None
 0.87A 3gssA-3tehA:
undetectable		 3gssA-3tehA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 7 TYR A 307
PHE A 291
VAL A 294
THR A 179
 None
 0.83A 3gssB-3tehA:
undetectable		 3gssB-3tehA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 12 ARG A 204
GLN A 218
PHE A 258
GLY A 281
GLY A 316
 DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 ( 3.8A)
None
DAH  A 351 (-2.9A)
 0.93A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		6 / 12 ARG A 204
GLN A 218
PHE A 258
PHE A 260
GLY A 282
GLY A 264
 DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 ( 3.8A)
DAH  A 351 (-4.8A)
DAH  A 351 (-4.0A)
None
 1.38A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		10 / 12 SER A 180
ARG A 204
GLN A 218
GLU A 220
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 DAH  A 351 (-2.9A)
DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 (-3.3A)
DAH  A 351 ( 3.8A)
DAH  A 351 (-4.8A)
DAH  A 351 (-4.0A)
DAH  A 351 (-4.6A)
DAH  A 351 (-3.0A)
DAH  A 351 (-2.9A)
 0.50A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		10 / 12 SER A 180
GLN A 183
ARG A 204
GLN A 218
PHE A 258
PHE A 260
GLY A 282
GLY A 284
ALA A 314
GLY A 316
 DAH  A 351 (-2.9A)
DAH  A 351 ( 4.3A)
DAH  A 351 (-3.7A)
DAH  A 351 (-2.8A)
DAH  A 351 ( 3.8A)
DAH  A 351 (-4.8A)
DAH  A 351 (-4.0A)
DAH  A 351 (-4.6A)
DAH  A 351 (-3.0A)
DAH  A 351 (-2.9A)
 0.46A 3tegA-3tehA:
23.2		 3tegA-3tehA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 TYR A 119
MET A 106
LEU A 244
 None
 1.00A 3vw1D-3tehA:
undetectable		 3vw1D-3tehA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		4 / 4 LEU A 110
LEU A 105
GLN A 218
GLU A 123
 None
None
DAH  A 351 (-2.8A)
None
 1.14A 4i41A-3tehA:
1.2		 4i41A-3tehA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 9 PHE A 245
SER A 249
ALA A 268
LEU A 280
ALA A 210
 None
 1.42A 4l6va-3tehA:
undetectable
4l6vf-3tehA:
undetectable		 4l6va-3tehA:
19.05
4l6vf-3tehA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 11 TYR A 297
TYR A 307
LEU A 165
LEU A 301
ARG A 298
 None
 1.48A 4m7tA-3tehA:
undetectable		 4m7tA-3tehA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.66A 5qgyA-3tehA:
undetectable		 5qgyA-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.65A 5qgzA-3tehA:
undetectable		 5qgzA-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.66A 5qh0A-3tehA:
undetectable		 5qh0A-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.64A 5qh2A-3tehA:
undetectable		 5qh2A-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.66A 5qh3A-3tehA:
undetectable		 5qh3A-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.68A 5qh6A-3tehA:
undetectable		 5qh6A-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.68A 5qh7A-3tehA:
undetectable		 5qh7A-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		3 / 3 VAL A 269
VAL A 251
GLN A 242
 None
 0.65A 5qhaA-3tehA:
undetectable		 5qhaA-3tehA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 VAL A 310
ALA A 306
ASP A 295
PHE A 291
VAL A 224
 None
 1.15A 6aogA-3tehA:
undetectable		 6aogA-3tehA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 VAL A 310
ALA A 306
ASP A 295
PHE A 291
VAL A 224
 None
 1.12A 6aogB-3tehA:
undetectable		 6aogB-3tehA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLU A 206
HIS A 212
PHE A 216
GLY A 318
ILE A 332
 None
 0.86A 6bniA-3tehA:
5.3		 6bniA-3tehA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
(Thermus
thermophilus) 		5 / 10 GLU A 206
HIS A 212
PHE A 216
GLY A 318
ILE A 332
 None
 0.93A 6bniB-3tehA:
13.7		 6bniB-3tehA:
10.86