SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 LEU A  85
SER A  67
LEU A  60
GLY A 119
 None
 0.91A 1a4lC-3tfoA:
undetectable		 1a4lC-3tfoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A 150
VAL A 152
TRP A 105
 None
 0.96A 1gmkC-3tfoA:
undetectable
1gmkD-3tfoA:
undetectable		 1gmkC-3tfoA:
4.67
1gmkD-3tfoA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A  74
LEU A  60
ALA A  35
ALA A  12
LEU A  32
 None
 0.96A 1jinA-3tfoA:
undetectable		 1jinA-3tfoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 9 ILE A  41
GLY A  14
ILE A  44
ALA A  43
GLU A  47
 None
 1.03A 1mrgA-3tfoA:
undetectable		 1mrgA-3tfoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 ILE A  41
GLY A  14
ILE A  44
GLU A  47
 None
 0.84A 1mrjA-3tfoA:
undetectable		 1mrjA-3tfoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		7 / 11 GLY A  11
ALA A  12
ASP A  61
VAL A  62
ALA A  89
VAL A  91
VAL A 111
 None
 1.34A 1uayA-3tfoA:
26.9		 1uayA-3tfoA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		7 / 10 GLY A  11
ALA A  12
ASP A  61
VAL A  62
ALA A  89
VAL A  91
VAL A 111
 None
 1.33A 1uayB-3tfoA:
27.0		 1uayB-3tfoA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 6 ARG A 168
ASP A 229
THR A 231
ASP A 165
 None
 1.18A 2j2pE-3tfoA:
undetectable
2j2pF-3tfoA:
undetectable		 2j2pE-3tfoA:
20.85
2j2pF-3tfoA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		7 / 12 MET A  92
LEU A  94
SER A 140
ILE A 141
VAL A 147
ALA A 150
TYR A 153
 None
 0.64A 2japA-3tfoA:
34.5		 2japA-3tfoA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 12 MET A  92
LEU A  94
SER A 140
ILE A 141
ALA A 150
TYR A 153
 None
 0.61A 2japB-3tfoA:
34.5		 2japB-3tfoA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 12 MET A  92
LEU A  94
SER A 140
VAL A 147
ALA A 150
TYR A 153
 None
 0.40A 2japB-3tfoA:
34.5		 2japB-3tfoA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		7 / 12 MET A  92
LEU A  94
SER A 140
ILE A 141
VAL A 147
ALA A 150
TYR A 153
 None
 0.65A 2japC-3tfoA:
34.4		 2japC-3tfoA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 12 MET A  92
LEU A  94
SER A 140
ILE A 141
ALA A 150
TYR A 153
 None
 0.61A 2japD-3tfoA:
34.5		 2japD-3tfoA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 12 MET A  92
LEU A  94
SER A 140
VAL A 147
ALA A 150
TYR A 153
 None
 0.39A 2japD-3tfoA:
34.5		 2japD-3tfoA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 LEU A  85
VAL A  68
ALA A  69
VAL A  76
ILE A  82
 None
 0.94A 2nnjA-3tfoA:
undetectable		 2nnjA-3tfoA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A  35
GLY A  17
ILE A  20
ALA A  45
ILE A  41
 None
 1.03A 3ekwA-3tfoA:
undetectable		 3ekwA-3tfoA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A  22
GLN A 220
VAL A 221
ILE A   9
ILE A  16
 None
HEZ  A 265 ( 3.8A)
HEZ  A 265 ( 4.9A)
None
None
 1.05A 3ganA-3tfoA:
undetectable		 3ganA-3tfoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  33
GLY A  34
ILE A  31
ALA A  75
ASP A  83
 None
 0.92A 3gwvA-3tfoA:
undetectable		 3gwvA-3tfoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  33
GLY A  34
ILE A  31
ALA A  75
ASP A  83
 None
 0.92A 3gwwA-3tfoA:
undetectable		 3gwwA-3tfoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A 138
ILE A   9
ILE A 214
ALA A  21
GLU A  23
 None
 1.10A 3tmzA-3tfoA:
undetectable		 3tmzA-3tfoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A 138
ILE A 214
ALA A  21
GLU A  23
VAL A  86
 None
 1.08A 3tmzA-3tfoA:
undetectable		 3tmzA-3tfoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 LEU A  60
ALA A  74
VAL A 123
ILE A  82
 None
 0.96A 4xe3A-3tfoA:
undetectable		 4xe3A-3tfoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 LEU A  60
ALA A  74
VAL A 123
ILE A  82
 None
 0.88A 4xe3B-3tfoA:
undetectable		 4xe3B-3tfoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 9 ILE A  41
GLY A  14
ILE A  44
ALA A  43
GLU A  47
 None
 0.90A 4yp2B-3tfoA:
undetectable		 4yp2B-3tfoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 9 ILE A  41
GLY A  14
ILE A  44
ALA A  43
GLU A  47
 None
 0.92A 5cf9B-3tfoA:
undetectable		 5cf9B-3tfoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 6 SER A 164
GLY A 139
ASN A 180
ILE A 136
 None
 1.14A 5j4nA-3tfoA:
undetectable		 5j4nA-3tfoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  85
GLY A  11
GLY A  34
ILE A  20
ILE A 138
 None
 0.96A 6ecxA-3tfoA:
5.9		 6ecxA-3tfoA:
20.25