SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		3 / 3 GLU A  93
HIS A  98
ASP A 141
 None
 0.34A 1i9gA-3tfwA:
19.8		 1i9gA-3tfwA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 5 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.47A 1p6kB-3tfwA:
undetectable		 1p6kB-3tfwA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 5 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.47A 1rs6B-3tfwA:
undetectable		 1rs6B-3tfwA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 5 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.46A 1zzqB-3tfwA:
undetectable		 1zzqB-3tfwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 5 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.48A 1zzuA-3tfwA:
undetectable		 1zzuA-3tfwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 5 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.48A 1zzuB-3tfwA:
undetectable		 1zzuB-3tfwA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		6 / 12 GLY A  69
TYR A  74
ALA A 122
ALA A 142
ASP A 143
TYR A 150
 None
 0.66A 2avdA-3tfwA:
27.0		 2avdA-3tfwA:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		6 / 12 GLY A  69
TYR A  74
ALA A 122
ASP A 141
ALA A 142
TYR A 150
 None
 0.67A 2avdB-3tfwA:
27.0		 2avdB-3tfwA:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		3 / 3 GLY A  69
GLU A  93
ASP A 141
 None
 0.26A 2b25B-3tfwA:
15.3		 2b25B-3tfwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 8 ARG A 118
THR A 116
VAL A 115
LEU A  89
 None
 0.99A 3ax7A-3tfwA:
undetectable		 3ax7A-3tfwA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 GLU A  67
GLY A  69
GLU A  93
ASP A  95
ALA A 122
 None
 0.53A 3gryA-3tfwA:
14.1		 3gryA-3tfwA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 4 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.48A 4kcnB-3tfwA:
1.4		 4kcnB-3tfwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A  69
ASP A  95
ALA A 122
ALA A 142
TYR A 150
 None
 0.64A 4pclA-3tfwA:
28.1		 4pclA-3tfwA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 GLU A  67
GLY A  69
ALA A 122
ALA A 142
TYR A 150
 None
 0.26A 4pclB-3tfwA:
28.0		 4pclB-3tfwA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 151
THR A 218
ALA A 220
VAL A 222
ILE A 164
 None
 1.02A 4x1yD-3tfwA:
3.3		 4x1yD-3tfwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 151
THR A 218
ALA A 220
VAL A 222
ILE A 164
 None
 1.02A 4x20D-3tfwA:
3.9		 4x20D-3tfwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A  69
TYR A  74
ALA A 122
ALA A 142
TYR A 150
 None
 0.54A 4ymgA-3tfwA:
25.1		 4ymgA-3tfwA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A  69
ALA A 122
ASP A 141
ALA A 142
TYR A 150
 None
 0.46A 4ymgB-3tfwA:
25.5		 4ymgB-3tfwA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A  69
TYR A  74
ALA A 122
ALA A 142
TYR A 150
 None
 0.52A 4ymgB-3tfwA:
25.5		 4ymgB-3tfwA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		3 / 3 GLU A  93
HIS A  98
ASP A 141
 None
 0.47A 5c0oG-3tfwA:
18.3		 5c0oG-3tfwA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 6 VAL A 111
LEU A  53
ILE A 165
PHE A 139
 None
 0.89A 5jw1A-3tfwA:
undetectable		 5jw1A-3tfwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 10 LEU A  17
ASN A  48
ALA A  46
GLY A 213
VAL A  13
 None
 1.04A 5kr1A-3tfwA:
undetectable		 5kr1A-3tfwA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A  17
ASN A  48
ALA A  46
GLY A 213
VAL A  13
 None
 0.91A 5kr2B-3tfwA:
undetectable		 5kr2B-3tfwA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		8 / 12 GLU A  67
GLY A  69
TYR A  74
ALA A 122
ASP A 141
ALA A 142
ASP A 143
TYR A 150
 None
 0.70A 5kvaA-3tfwA:
22.8		 5kvaA-3tfwA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		8 / 12 GLU A  67
GLY A  69
TYR A  74
ALA A 122
ASP A 141
ALA A 142
ASP A 143
TYR A 150
 None
 0.75A 5kvaB-3tfwA:
22.8		 5kvaB-3tfwA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 6 ASP A 141
LYS A 144
ASP A 167
ASN A 168
 None
 1.16A 5logA-3tfwA:
28.9		 5logA-3tfwA:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		6 / 12 GLU A  67
GLY A  69
TYR A  74
GLU A 119
PHE A 139
TYR A 150
 None
 1.50A 5n5dA-3tfwA:
33.5		 5n5dA-3tfwA:
43.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		8 / 12 VAL A  45
GLU A  67
GLY A  69
TYR A  74
ALA A 122
PHE A 139
ALA A 142
TYR A 150
 None
 0.46A 5n5dA-3tfwA:
33.5		 5n5dA-3tfwA:
43.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		7 / 12 VAL A  45
GLU A  67
TYR A  74
ALA A 122
PHE A 139
ALA A 142
TYR A 150
 None
 0.51A 5n5dB-3tfwA:
33.7		 5n5dB-3tfwA:
43.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 5 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.49A 5vunA-3tfwA:
undetectable		 5vunA-3tfwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 4 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.46A 5vunB-3tfwA:
1.0		 5vunB-3tfwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 6 GLY A  73
TYR A  74
LEU A  89
VAL A 111
 None
 0.80A 5x80A-3tfwA:
undetectable
5x80B-3tfwA:
undetectable		 5x80A-3tfwA:
23.60
5x80B-3tfwA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A  28
ARG A  81
ILE A  22
LEU A 163
LEU A  59
 None
 0.99A 5ycnA-3tfwA:
undetectable		 5ycnA-3tfwA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 GLU A  67
GLY A  69
TYR A  74
ALA A 122
ALA A 142
 None
 0.57A 5zw4A-3tfwA:
24.7		 5zw4A-3tfwA:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tfw PUTATIVE
O-METHYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 4 GLY A 216
GLN A 207
TRP A 214
VAL A 209
 None
 1.45A 6auuB-3tfwA:
0.9		 6auuB-3tfwA:
18.33