SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		5 / 12 PRO A  27
LEU A  50
TYR A  55
LEU A  38
LEU A  11
 None
 0.92A 1e7wA-3tfxA:
undetectable		 1e7wA-3tfxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		4 / 7 LYS A 152
LEU A 178
ASP A 176
SER A 209
 None
 1.39A 3dzgA-3tfxA:
undetectable		 3dzgA-3tfxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		5 / 11 VAL A 213
VAL A 119
LEU A 122
ILE A 160
THR A 123
 None
 1.31A 3elzB-3tfxA:
undetectable		 3elzB-3tfxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		4 / 5 ILE A  96
ALA A  89
HIS A 153
MET A 150
 None
 1.21A 4ac9B-3tfxA:
2.4
4ac9C-3tfxA:
2.3		 4ac9B-3tfxA:
21.11
4ac9C-3tfxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		4 / 5 ILE A  96
ALA A  89
HIS A 153
MET A 150
 None
 1.21A 4acaB-3tfxA:
2.5
4acaC-3tfxA:
2.3		 4acaB-3tfxA:
21.11
4acaC-3tfxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		5 / 12 ILE A  57
VAL A  34
LEU A  59
ALA A  42
LEU A  50
 None
 1.02A 4m11B-3tfxA:
undetectable		 4m11B-3tfxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		5 / 12 LEU A  11
LEU A  61
MET A  63
ILE A  82
LEU A  80
 None
 1.27A 5ienA-3tfxA:
undetectable		 5ienA-3tfxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		4 / 7 ALA A   8
THR A 218
ILE A  20
LEU A  24
 None
 1.01A 5te8A-3tfxA:
undetectable		 5te8A-3tfxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		5 / 12 ILE A  57
THR A  83
THR A  86
VAL A  87
VAL A 119
 None
 1.31A 6bzoC-3tfxA:
undetectable		 6bzoC-3tfxA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		4 / 7 ASN A 235
ALA A 236
LYS A 201
GLU A 205
 None
 1.05A 6ci6A-3tfxA:
undetectable		 6ci6A-3tfxA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		4 / 6 LEU A 219
THR A 218
GLY A 214
ARG A 185
 None
 0.80A 6gtqB-3tfxA:
0.0
6gtqD-3tfxA:
undetectable		 6gtqB-3tfxA:
21.01
6gtqD-3tfxA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		5 / 12 PRO A 186
ILE A 230
ILE A 184
VAL A   5
ILE A 211
 None
 1.20A 6hlpA-3tfxA:
undetectable		 6hlpA-3tfxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Lactobacillus
acidophilus) 		4 / 7 GLY A 158
PHE A 177
SER A 208
SER A 209
 None
 0.95A 6jnhA-3tfxA:
undetectable		 6jnhA-3tfxA:
20.07