SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.01A 1cqeA-3tfyA:
undetectable		 1cqeA-3tfyA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.02A 1cqeB-3tfyA:
undetectable		 1cqeB-3tfyA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.02A 1eqhA-3tfyA:
undetectable		 1eqhA-3tfyA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.06A 2aylA-3tfyA:
undetectable		 2aylA-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.03A 2aylB-3tfyA:
undetectable		 2aylB-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A  33
TYR A  36
LYS A  17
 None
 1.13A 2othA-3tfyA:
undetectable		 2othA-3tfyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.01A 3ln1C-3tfyA:
undetectable		 3ln1C-3tfyA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.04A 3n8wA-3tfyA:
undetectable		 3n8wA-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
LEU A   8
ILE A  88
LEU A  22
LEU A  19
 None
None
COA  A 201 (-4.2A)
None
None
 0.78A 3n8yB-3tfyA:
undetectable		 3n8yB-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.97A 3n8zA-3tfyA:
undetectable		 3n8zA-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.00A 3n8zB-3tfyA:
undetectable		 3n8zB-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.02A 3nt1A-3tfyA:
undetectable		 3nt1A-3tfyA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.03A 3nt1B-3tfyA:
undetectable		 3nt1B-3tfyA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.99A 3pghB-3tfyA:
undetectable		 3pghB-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.98A 3pghC-3tfyA:
undetectable		 3pghC-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.98A 3pghD-3tfyA:
undetectable		 3pghD-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.97A 3rr3A-3tfyA:
undetectable		 3rr3A-3tfyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.98A 3rr3B-3tfyA:
undetectable		 3rr3B-3tfyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.98A 3rr3C-3tfyA:
undetectable		 3rr3C-3tfyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.98A 3rr3D-3tfyA:
undetectable		 3rr3D-3tfyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.96A 4coxA-3tfyA:
undetectable		 4coxA-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.96A 4coxB-3tfyA:
undetectable		 4coxB-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.96A 4coxC-3tfyA:
undetectable		 4coxC-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.95A 4coxD-3tfyA:
undetectable		 4coxD-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.99A 4otyB-3tfyA:
undetectable		 4otyB-3tfyA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 117
SER A 119
ARG A  84
 COA  A 201 (-3.3A)
COA  A 201 (-3.8A)
COA  A 201 (-3.9A)
 0.83A 5b2qA-3tfyA:
undetectable		 5b2qA-3tfyA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.97A 5ikqA-3tfyA:
undetectable		 5ikqA-3tfyA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.02A 5jvzA-3tfyA:
undetectable		 5jvzA-3tfyA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.99A 5jvzB-3tfyA:
undetectable		 5jvzB-3tfyA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 GLN A 114
VAL A 113
PRO A 144
ILE A 121
 None
 0.80A 6cduF-3tfyA:
undetectable
6cduG-3tfyA:
undetectable		 6cduF-3tfyA:
20.30
6cduG-3tfyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 GLN A 114
VAL A 113
PRO A 144
ILE A 121
 None
 0.92A 6cduG-3tfyA:
undetectable
6cduH-3tfyA:
undetectable		 6cduG-3tfyA:
20.30
6cduH-3tfyA:
20.30