SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 VAL A  53
VAL A  37
TRP A  62
 None
None
CXS  A 171 (-4.4A)
 0.69A 1av2C-3tfzA:
undetectable
1av2D-3tfzA:
undetectable		 1av2C-3tfzA:
11.00
1av2D-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		5 / 9 THR A  34
VAL A  24
GLY A  26
VAL A 150
ASP A 146
 None
None
None
None
CXS  A 171 (-4.7A)
 1.36A 1dz8A-3tfzA:
undetectable		 1dz8A-3tfzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		5 / 9 THR A  34
VAL A  24
GLY A  26
VAL A 150
ASP A 146
 None
None
None
None
CXS  A 171 (-4.7A)
 1.33A 1dz8B-3tfzA:
undetectable		 1dz8B-3tfzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		5 / 9 THR A  34
VAL A  24
GLY A  26
VAL A 150
ASP A 146
 None
None
None
None
CXS  A 171 (-4.7A)
 1.33A 1dz9B-3tfzA:
undetectable		 1dz9B-3tfzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 VAL A  53
VAL A  37
TRP A  62
 None
None
CXS  A 171 (-4.4A)
 0.71A 1w5uC-3tfzA:
undetectable
1w5uD-3tfzA:
undetectable		 1w5uC-3tfzA:
11.00
1w5uD-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		5 / 9 THR A  34
VAL A  24
GLY A  26
VAL A 150
ASP A 146
 None
None
None
None
CXS  A 171 (-4.7A)
 1.36A 2a1oB-3tfzA:
undetectable		 2a1oB-3tfzA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		5 / 10 THR A  34
VAL A  24
GLY A  26
VAL A 150
ASP A 146
 None
None
None
None
CXS  A 171 (-4.7A)
 1.32A 2cp4A-3tfzA:
undetectable		 2cp4A-3tfzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 VAL A  37
TRP A  62
VAL A  53
 None
CXS  A 171 (-4.4A)
None
 0.85A 2izqA-3tfzA:
undetectable
2izqB-3tfzA:
undetectable		 2izqA-3tfzA:
11.00
2izqB-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		5 / 10 ALA A 137
ASN A  60
ALA A  83
ILE A  85
LEU A 126
 None
 1.23A 3fl9F-3tfzA:
undetectable		 3fl9F-3tfzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 VAL A  53
VAL A  37
TRP A  62
 None
None
CXS  A 171 (-4.4A)
 0.76A 3l8lA-3tfzA:
undetectable
3l8lB-3tfzA:
undetectable		 3l8lA-3tfzA:
11.00
3l8lB-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 VAL A  53
VAL A  37
TRP A  62
 None
None
CXS  A 171 (-4.4A)
 0.68A 3l8lC-3tfzA:
undetectable
3l8lD-3tfzA:
undetectable		 3l8lC-3tfzA:
11.00
3l8lD-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 GLU A  38
THR A  61
HIS A  52
 None
 0.87A 4q15A-3tfzA:
undetectable		 4q15A-3tfzA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 GLU A  38
THR A  61
HIS A  52
 None
 0.86A 4q15B-3tfzA:
undetectable		 4q15B-3tfzA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		3 / 3 GLU A  38
THR A  61
HIS A  52
 None
 0.76A 4ydqB-3tfzA:
undetectable		 4ydqB-3tfzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3tfz CYCLASE
(Streptomyces
sp.
R1128) 		4 / 6 SER A  64
GLN A  47
GLU A  38
THR A  61
 CXS  A 171 (-2.9A)
None
None
None
 1.28A 6djzA-3tfzA:
undetectable		 6djzA-3tfzA:
23.87