SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 6 PHE B 276
ILE B 234
LYS B 157
ALA B 156
 None
 1.27A 1hk2A-3tg1B:
undetectable		 1hk2A-3tg1B:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 4 LEU B 155
PRO B 152
LEU B 269
ARG B 178
 None
 1.32A 2hrcA-3tg1B:
undetectable		 2hrcA-3tg1B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 4 LEU B 155
PRO B 152
LEU B 269
ARG B 178
 None
 1.26A 3hcoB-3tg1B:
2.4		 3hcoB-3tg1B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 7 ASP B 176
ARG B 178
GLY B 272
GLU B 238
 None
 0.97A 5btaA-3tg1B:
undetectable
5btaC-3tg1B:
undetectable
5btaD-3tg1B:
2.8		 5btaA-3tg1B:
12.96
5btaC-3tg1B:
12.96
5btaD-3tg1B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 7 ASP B 176
ARG B 178
GLY B 272
GLU B 238
 None
 0.94A 5btdA-3tg1B:
undetectable
5btdC-3tg1B:
undetectable
5btdD-3tg1B:
2.8		 5btdA-3tg1B:
14.53
5btdC-3tg1B:
14.53
5btdD-3tg1B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 7 ASP B 176
ARG B 178
GLY B 272
GLU B 238
 None
 0.96A 5btfA-3tg1B:
undetectable
5btfB-3tg1B:
3.0
5btfC-3tg1B:
undetectable		 5btfA-3tg1B:
12.96
5btfB-3tg1B:
18.85
5btfC-3tg1B:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 7 ASP B 176
ARG B 178
GLY B 272
GLU B 238
 None
 0.92A 5btfA-3tg1B:
undetectable
5btfC-3tg1B:
undetectable
5btfD-3tg1B:
2.8		 5btfA-3tg1B:
12.96
5btfC-3tg1B:
12.96
5btfD-3tg1B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3tg1 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 9 LEU B 256
ILE B 175
ILE B 149
GLU B 242
GLU B 265
 None
 1.33A 5igzA-3tg1B:
undetectable		 5igzA-3tg1B:
18.42