SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EYS_A_ACTA402_0 (MCCC FAMILY PROTEIN)	3tg3	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16 (Homo sapiens)	4 / 6	ASP A 89 SER A 31 ASP A 30 GLU A 36	None	1.25A	4eysA-3tg3A: undetectable	4eysA-3tg3A: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NX6_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	3tg3	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16 (Homo sapiens)	5 / 12	ALA A 73 LEU A 27 ILE A 65 LEU A 111 ILE A 48	None	1.10A	4nx6A-3tg3A: undetectable	4nx6A-3tg3A: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NX7_A_FOLA202_0 (DIHYDROFOLATE REDUCTASE)	3tg3	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16 (Homo sapiens)	5 / 12	ALA A 73 LEU A 27 ILE A 65 LEU A 111 ILE A 48	None	1.11A	4nx7A-3tg3A: undetectable	4nx7A-3tg3A: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PST_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	3tg3	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16 (Homo sapiens)	5 / 12	ALA A 73 LEU A 27 ILE A 65 LEU A 111 ILE A 48	None	1.03A	4pstA-3tg3A: undetectable	4pstA-3tg3A: 21.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4EYS_A_ACTA402_0","MCCC FAMILY PROTEIN","3tg3","DUAL SPECIFICITY PROTEIN PHOSPHATASE 16","Homo sapiens",4,"ASP A  89;SER A  31;ASP A  30;GLU A  36","None","1.25A","4eysA-3tg3A:undetectable","4eysA-3tg3A:18.02"],["4NX6_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","3tg3","DUAL SPECIFICITY PROTEIN PHOSPHATASE 16","Homo sapiens",5,"ALA A  73;LEU A  27;ILE A  65;LEU A 111;ILE A  48","None","1.10A","4nx6A-3tg3A:undetectable","4nx6A-3tg3A:21.30"],["4NX7_A_FOLA202_0","DIHYDROFOLATE REDUCTASE","3tg3","DUAL SPECIFICITY PROTEIN PHOSPHATASE 16","Homo sapiens",5,"ALA A  73;LEU A  27;ILE A  65;LEU A 111;ILE A  48","None","1.11A","4nx7A-3tg3A:undetectable","4nx7A-3tg3A:21.30"],["4PST_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","3tg3","DUAL SPECIFICITY PROTEIN PHOSPHATASE 16","Homo sapiens",5,"ALA A  73;LEU A  27;ILE A  65;LEU A 111;ILE A  48","None","1.03A","4pstA-3tg3A:undetectable","4pstA-3tg3A:21.30"]]