SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		5 / 11 GLY A  36
GLY A 276
GLN A  42
GLY A  65
GLY A 255
 None
 1.11A 1mxgA-3tghA:
undetectable		 1mxgA-3tghA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		4 / 8 GLY A 298
ILE A 297
ASN A 258
SER A 275
 None
 0.95A 2a8tB-3tghA:
undetectable		 2a8tB-3tghA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		4 / 7 PHE A  60
SER A  31
LEU A 304
ILE A 253
 None
 0.87A 2v0mC-3tghA:
undetectable		 2v0mC-3tghA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		5 / 11 ALA A 174
ALA A 213
VAL A 218
LEU A 206
GLN A 205
 None
 1.04A 3bszE-3tghA:
undetectable		 3bszE-3tghA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		5 / 12 ALA A  30
GLY A 319
THR A 324
VAL A 310
THR A 311
 None
 1.10A 3c6gB-3tghA:
undetectable		 3c6gB-3tghA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		5 / 10 ALA A 176
LEU A 206
VAL A 249
ILE A 180
LEU A 240
 None
 1.06A 3jw3A-3tghA:
undetectable		 3jw3A-3tghA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		4 / 7 PHE A  29
TYR A 153
HIS A 152
VAL A 102
 None
 0.97A 4a97A-3tghA:
undetectable		 4a97A-3tghA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		4 / 6 PHE A  29
TYR A 153
HIS A 152
VAL A 102
 None
 1.05A 4a97E-3tghA:
undetectable		 4a97E-3tghA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		4 / 6 PHE A  29
TYR A 153
HIS A 152
VAL A 102
 None
 0.98A 4a97I-3tghA:
undetectable		 4a97I-3tghA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		5 / 9 ILE A 145
ILE A  61
PHE A  49
TYR A  88
TYR A  84
 None
None
None
None
DMS  A 366 ( 4.4A)
 1.19A 4afgA-3tghA:
undetectable
4afgE-3tghA:
undetectable		 4afgA-3tghA:
20.81
4afgE-3tghA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		5 / 9 TYR A  88
TYR A  84
ILE A 145
ILE A  61
PHE A  49
 None
DMS  A 366 ( 4.4A)
None
None
None
 1.23A 4afgB-3tghA:
0.0
4afgC-3tghA:
0.0		 4afgB-3tghA:
20.81
4afgC-3tghA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		4 / 8 GLY A 276
GLY A  36
LEU A  83
VAL A  87
 None
 0.86A 4fgzB-3tghA:
undetectable		 4fgzB-3tghA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		4 / 4 THR A 105
GLY A 255
ASP A 257
SER A  66
 None
 1.26A 4rfqA-3tghA:
undetectable		 4rfqA-3tghA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3tgh GLIDEOSOME-ASSOCIATE
D PROTEIN 50
(Plasmodium
falciparum) 		5 / 12 VAL A 310
ILE A 309
ILE A 253
PHE A  29
ILE A 322
 None
 1.28A 6mkeB-3tghA:
undetectable
6mkeC-3tghA:
undetectable		 6mkeB-3tghA:
11.08
6mkeC-3tghA:
11.08