SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 10 LEU A 155
VAL A 107
VAL A 102
TYR A 187
LEU A 151
 None
 1.00A 1fkoA-3tglA:
undetectable		 1fkoA-3tglA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		4 / 4 LEU A  23
GLY A  69
ASP A  48
TYR A  19
 None
 1.18A 1oxrA-3tglA:
undetectable		 1oxrA-3tglA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		3 / 3 ARG A 197
SER A 114
TYR A 115
 None
 0.75A 1x70A-3tglA:
undetectable		 1x70A-3tglA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 12 ILE A  85
GLY A 266
LEU A 267
VAL A  32
SER A 114
 None
 1.21A 1zq9A-3tglA:
undetectable		 1zq9A-3tglA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 10 VAL A 138
LEU A 122
VAL A  66
VAL A 126
LEU A 157
 None
 0.96A 3gwxA-3tglA:
undetectable		 3gwxA-3tglA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 12 VAL A 188
GLY A 147
ALA A 148
LEU A 152
LEU A 155
 None
 0.78A 3n8yB-3tglA:
0.1		 3n8yB-3tglA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 12 VAL A 205
HIS A 257
ASP A 203
GLY A  81
SER A 144
 None
 0.93A 3sufB-3tglA:
undetectable		 3sufB-3tglA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 11 ALA A 183
ASP A 181
PHE A 111
LEU A 151
VAL A 188
 None
 1.45A 4eilA-3tglA:
undetectable		 4eilA-3tglA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 11 ALA A 183
ASP A 181
PHE A 111
LEU A 151
VAL A 188
 None
 1.42A 4kyaA-3tglA:
undetectable		 4kyaA-3tglA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 10 ALA A 183
ASP A 181
PHE A 111
LEU A 151
VAL A 188
 None
 1.41A 4kyaC-3tglA:
undetectable		 4kyaC-3tglA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 11 ALA A 183
ASP A 181
PHE A 111
LEU A 151
VAL A 188
 None
 1.43A 4kyaE-3tglA:
undetectable		 4kyaE-3tglA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 11 ALA A 183
ASP A 181
PHE A 111
LEU A 151
VAL A 188
 None
 1.39A 4kyaG-3tglA:
undetectable		 4kyaG-3tglA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		3 / 3 LYS A 131
ASN A 168
ASP A 128
 None
 0.75A 4o1eA-3tglA:
undetectable		 4o1eA-3tglA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		4 / 5 GLU A  13
GLU A  16
TYR A 172
TYR A 222
 None
 1.22A 4twdA-3tglA:
undetectable
4twdE-3tglA:
0.0		 4twdA-3tglA:
21.58
4twdE-3tglA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		4 / 4 TYR A  99
THR A 105
GLY A 180
LEU A 151
 None
 1.08A 4w5nA-3tglA:
undetectable		 4w5nA-3tglA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 12 LEU A 122
GLY A 146
GLY A  81
ASN A  63
CYH A 153
 None
 1.30A 4x61A-3tglA:
2.4		 4x61A-3tglA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		4 / 4 LEU A 258
ILE A  89
HIS A 257
VAL A 254
 None
 1.17A 4xyzA-3tglA:
undetectable		 4xyzA-3tglA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		3 / 3 TYR A 172
THR A 198
THR A 141
 None
 0.73A 5aoxB-3tglA:
undetectable		 5aoxB-3tglA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		3 / 3 TYR A 172
THR A 198
THR A 141
 None
 0.74A 5aoxE-3tglA:
undetectable		 5aoxE-3tglA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		3 / 3 ASP A 243
ARG A 178
ARG A 197
 None
 0.97A 5eajB-3tglA:
undetectable		 5eajB-3tglA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		4 / 6 GLU A 162
ARG A 160
ASP A 156
ASP A 128
 None
 1.07A 5zw4A-3tglA:
undetectable		 5zw4A-3tglA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 12 HIS A 257
ILE A  85
SER A  82
HIS A 143
ASP A 203
 None
 1.13A 6n91A-3tglA:
2.6		 6n91A-3tglA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE
(Rhizomucor
miehei) 		5 / 12 HIS A 257
ILE A  85
SER A  82
HIS A 143
ASP A 203
 None
 1.14A 6n91B-3tglA:
2.6		 6n91B-3tglA:
14.13