SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		3 / 4 LYS A   6
ALA A   5
MET A   1
 None
 0.99A 1hk3A-3tgnA:
undetectable		 1hk3A-3tgnA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		4 / 8 LEU A  61
HIS A 108
GLU A  24
HIS A 112
 None
ZN  A 147 (-3.2A)
ZN  A 147 (-2.1A)
ZN  A 147 (-3.2A)
 0.85A 2bnnA-3tgnA:
undetectable
2bnnB-3tgnA:
undetectable		 2bnnA-3tgnA:
25.63
2bnnB-3tgnA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		5 / 11 ILE A  72
ALA A  71
THR A  39
GLU A  50
LEU A  61
 None
 1.35A 2v0mD-3tgnA:
undetectable		 2v0mD-3tgnA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		3 / 3 GLU A 107
HIS A 109
HIS A 112
 ZN  A 148 (-2.3A)
None
ZN  A 147 (-3.2A)
 0.93A 3co4A-3tgnA:
undetectable		 3co4A-3tgnA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		4 / 5 ARG A 102
THR A  98
ASP A  99
GLU A  82
 None
 1.18A 3v5vC-3tgnA:
undetectable
3v5vD-3tgnA:
undetectable		 3v5vC-3tgnA:
14.87
3v5vD-3tgnA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		4 / 5 GLU A  82
ARG A 102
THR A  98
ASP A  99
 None
 1.22A 4e7cA-3tgnA:
undetectable
4e7cB-3tgnA:
undetectable		 4e7cA-3tgnA:
14.87
4e7cB-3tgnA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		4 / 6 LEU A  57
HIS A 108
HIS A 112
GLU A  24
 None
ZN  A 147 (-3.2A)
ZN  A 147 (-3.2A)
ZN  A 147 (-2.1A)
 0.93A 4pahA-3tgnA:
undetectable		 4pahA-3tgnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		3 / 3 LYS A   6
ASP A   7
ARG A   2
 None
 1.09A 5jwaA-3tgnA:
undetectable
5jwaH-3tgnA:
undetectable		 5jwaA-3tgnA:
15.46
5jwaH-3tgnA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		4 / 7 ARG A  59
ARG A  60
LEU A  61
ALA A  67
 None
 1.06A 6b89A-3tgnA:
undetectable		 6b89A-3tgnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3tgn ADC OPERON REPRESSOR
ADCR
(Streptococcus
pneumoniae) 		4 / 6 LEU A  57
HIS A 108
HIS A 112
GLU A  24
 None
ZN  A 147 (-3.2A)
ZN  A 147 (-3.2A)
ZN  A 147 (-2.1A)
 1.05A 6pahA-3tgnA:
undetectable		 6pahA-3tgnA:
16.88